PMID: 6110785Mar 1, 1981Paper

Association between Wilms tumor and gonadal dysgenesis

The Journal of Urology
J Rajfer

Abstract

The classification of intersexuality was determined in 10 patients with an intersex disorder who subsequently suffered a Wilms tumor. Of these 10 patients 7 (70 per cent) had a disorder of gonadal dysgenesis: 5 had mixed gonadal dysgenesis, 1 had dysgenetic male pseudohermaphroditism and 1 had 46XY pure gonadal dysgenesis. Because the gonads of patients with either of these 3 disorders have a high predilection for the development of testicular neoplasia, the concomitant occurrence of renal tumors in such a patient population suggests that a common defect in the urogenital ridge, the embryonic precursor of the kidneys and gonads, may be the cause of this association.

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Citations

Nov 1, 1991·Journal of Surgical Oncology·J G NirgiotisJ O Sherman
Jan 1, 1992·Acta Oncologica·M BüyükpamukçuC Akyüz
Aug 1, 1990·Journal of Paediatrics and Child Health·J M Hutson, G Werther
Jul 1, 1995·Journal of Clinical Ultrasound : JCU·M Barzilai
May 1, 1989·The Journal of Urology·J C JensenI Grunberger
Jun 1, 1991·The Journal of Urology·R K HeppeJ B Beckwith
Jun 1, 1994·Journal of Medical Genetics·R F Mueller
Dec 1, 1989·Ophthalmic Paediatrics and Genetics·W A Bickmore, N D Hastie

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