Association between worse metabolic control and increased thyroid volume and nodular disease in elderly adults with metabolic syndrome

Metabolic Syndrome and Related Disorders
Evelyn BlancGabriela Brenta

Abstract

Metabolic syndrome has been associated with nodular goiter. Our aim was to evaluate which metabolic parameters in elderly patients with metabolic syndrome are associated with thyroid enlargement or increased prevalence of thyroid nodules. In this cross-sectional study, 77 patients >65 years of age with metabolic syndrome were included. We evaluated the presence of thyroid nodules and thyroid volume by ultrasonography and several biochemical, metabolic and anthropometric parameters. Only patients with thyrotropin (thyroid-stimulating hormone, TSH) levels between 0.3 and 6 mU/L were included. We further divided subjects into two groups-type 2 diabetes mellitus (T2DM) and non-T2DM and established comparisons between them. Among all parameters analyzed we found a significant correlation between glycated hemoglobin (HbA1c) and volume (r=0.261, P=0.027) or number of nodules (r=0.266, P=0.023). Neither sex, age, body mass index (BMI), metformin, nor levothyroxine use were associated with thyroid volume or nodularity. Within the whole cohort, those patients with T2DM had larger thyroid volumes compared to non-T2DM [median (confidence interval, CI) 6.976 (5.220-10.789) vs. 5.034 (3.796-6.034) mL, P<0.008). Furthermore, a larger proporti...Continue Reading

References

Oct 9, 1981·Deutsche medizinische Wochenschrift·J BrunnP C Scriba
Sep 4, 1999·Journal of Endocrinological Investigation·D SilberschmidtM A Pisarev
Aug 2, 2005·The American Journal of Cardiology·Tracey McLaughlinRonald M Krauss
Sep 27, 2005·Arquivos brasileiros de endocrinologia e metabologia·Walkyria P PimentaCarlos R Padovani
Sep 5, 2006·Acta Radiologica·R JunikK Debska-Kozinska
Mar 19, 2008·Thyroid : Official Journal of the American Thyroid Association·Jorge RezzonicoHugo Niepomniszcze
Jul 27, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Mathilde JalvingElisabeth G E de Vries
Dec 3, 2010·The Journal of Clinical Endocrinology and Metabolism·Roberta MalaguarneraAntonino Belfiore
Dec 7, 2010·Metabolic Syndrome and Related Disorders·Jorge RezzónicoHugo Niepomniszcze
Jul 20, 2011·Thyroid : Official Journal of the American Thyroid Association·Briseis Aschebrook-KilfoyMary H Ward
Feb 15, 2013·Endocrinology·Maria C S SantosAndrea C F Ferreira
May 28, 2013·The Journal of Clinical Endocrinology and Metabolism·Joanna Klubo-GwiezdzinskaVasyl Vasko
Jul 25, 2013·Thyroid : Official Journal of the American Thyroid Association·Theodora Pappa, Maria Alevizaki
Nov 5, 2014·Thyroid : Official Journal of the American Thyroid Association·Ryan K OroscoMichael Bouvet

❮ Previous
Next ❯

Citations

Feb 16, 2017·The Journal of Endocrinology·Xianghui MengChao Liu
Dec 1, 2017·Frontiers in Endocrinology·Roberta MalaguarneraAntonino Belfiore
Jun 2, 2020·Colombia médica : CM·Raisa A MayersWilmer Gianfranco Silva Caso
May 4, 2018·International Journal of Endocrinology·Yi ChenYingli Lu
Apr 7, 2019·Scientific Reports·Maria Carmen Iglesias-OsmaJose Carretero
Jul 28, 2019·Current Medical Science·Hong-Mei ZhangXia Wang
Nov 22, 2017·International Journal of Endocrinology·Yunzhao TangChanglin Ni
Jul 25, 2019·Frontiers in Endocrinology·Stanley U Ogbonna, Ignatius U Ezeani
Mar 31, 2017·International Journal of Endocrinology·Dalia DauksieneBirute Zilaitiene

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Cardiomegaly

Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.

Related Papers

International Journal of Obesity : Journal of the International Association for the Study of Obesity
A NyrnesJ Sundsfjord
Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association
J J Díez, P Iglesias
© 2021 Meta ULC. All rights reserved