Abstract
Metabolic syndrome has been associated with nodular goiter. Our aim was to evaluate which metabolic parameters in elderly patients with metabolic syndrome are associated with thyroid enlargement or increased prevalence of thyroid nodules. In this cross-sectional study, 77 patients >65 years of age with metabolic syndrome were included. We evaluated the presence of thyroid nodules and thyroid volume by ultrasonography and several biochemical, metabolic and anthropometric parameters. Only patients with thyrotropin (thyroid-stimulating hormone, TSH) levels between 0.3 and 6 mU/L were included. We further divided subjects into two groups-type 2 diabetes mellitus (T2DM) and non-T2DM and established comparisons between them. Among all parameters analyzed we found a significant correlation between glycated hemoglobin (HbA1c) and volume (r=0.261, P=0.027) or number of nodules (r=0.266, P=0.023). Neither sex, age, body mass index (BMI), metformin, nor levothyroxine use were associated with thyroid volume or nodularity. Within the whole cohort, those patients with T2DM had larger thyroid volumes compared to non-T2DM [median (confidence interval, CI) 6.976 (5.220-10.789) vs. 5.034 (3.796-6.034) mL, P<0.008). Furthermore, a larger proporti...Continue Reading
References
Jul 1, 1985·Diabetologia·D R MatthewsR C Turner
Oct 9, 1981·Deutsche medizinische Wochenschrift·J BrunnP C Scriba
Sep 4, 1999·Journal of Endocrinological Investigation·D SilberschmidtM A Pisarev
Jul 29, 2003·Diabetes Care·Hisayo YokoyamaYoshiki Nishizawa
Aug 2, 2005·The American Journal of Cardiology·Tracey McLaughlinRonald M Krauss
Sep 27, 2005·Arquivos brasileiros de endocrinologia e metabologia·Walkyria P PimentaCarlos R Padovani
Sep 5, 2006·Acta Radiologica·R JunikK Debska-Kozinska
Aug 31, 2007·BMC Public Health·Bjørn HildrumAlv A Dahl
Mar 19, 2008·Thyroid : Official Journal of the American Thyroid Association·Jorge RezzonicoHugo Niepomniszcze
Jul 28, 2009·European Journal of Endocrinology·Semra AyturkNeslihan Bascil Tutuncu
Oct 7, 2009·Circulation·K G M M AlbertiUNKNOWN International Association for the Study of Obesity
Nov 20, 2009·Clinical Science·Ian F Godsland
May 21, 2010·Molecular Endocrinology·Sara BlancquaertPierre P Roger
Jul 27, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Mathilde JalvingElisabeth G E de Vries
Dec 3, 2010·The Journal of Clinical Endocrinology and Metabolism·Roberta MalaguarneraAntonino Belfiore
Dec 7, 2010·Metabolic Syndrome and Related Disorders·Jorge RezzónicoHugo Niepomniszcze
Jul 20, 2011·Thyroid : Official Journal of the American Thyroid Association·Briseis Aschebrook-KilfoyMary H Ward
Jan 27, 2012·The Journal of Clinical Endocrinology and Metabolism·Guofang ChenMichael Derwahl
Feb 12, 2013·Metabolism: Clinical and Experimental·Cuneyd AnilAlptekin Gursoy
Feb 15, 2013·Endocrinology·Maria C S SantosAndrea C F Ferreira
May 28, 2013·The Journal of Clinical Endocrinology and Metabolism·Joanna Klubo-GwiezdzinskaVasyl Vasko
Jul 25, 2013·Thyroid : Official Journal of the American Thyroid Association·Theodora Pappa, Maria Alevizaki
Jan 28, 2014·Endocrine-related Cancer·Fabian Pitoia
Nov 5, 2014·Thyroid : Official Journal of the American Thyroid Association·Ryan K OroscoMichael Bouvet
Citations
Feb 16, 2017·The Journal of Endocrinology·Xianghui MengChao Liu
Dec 1, 2017·Frontiers in Endocrinology·Roberta MalaguarneraAntonino Belfiore
Feb 12, 2019·Metabolic Syndrome and Related Disorders·Yue SuJin Xu
Mar 29, 2019·Endocrine·Wenxing GuoWanqi Zhang
Jun 2, 2020·Colombia médica : CM·Raisa A MayersWilmer Gianfranco Silva Caso
Jun 14, 2017·Mediators of Inflammation·Xiaoying DingYongde Peng
May 4, 2018·International Journal of Endocrinology·Yi ChenYingli Lu
Apr 7, 2019·Scientific Reports·Maria Carmen Iglesias-OsmaJose Carretero
Jul 28, 2019·Current Medical Science·Hong-Mei ZhangXia Wang
Sep 26, 2020·Frontiers in Endocrinology·Qijun LiangDongcai Li
Nov 22, 2017·International Journal of Endocrinology·Yunzhao TangChanglin Ni
Jul 25, 2019·Frontiers in Endocrinology·Stanley U Ogbonna, Ignatius U Ezeani
Mar 31, 2017·International Journal of Endocrinology·Dalia DauksieneBirute Zilaitiene
Dec 15, 2020·Environmental Pollution·Boying LiuYi Wang
Aug 30, 2021·BMC Endocrine Disorders·Yang XiaoChao Liu