Association between XPG polymorphisms and stomach cancer susceptibility in a Chinese population

Journal of Cellular and Molecular Medicine
Yunzhi ChenMeng-Tao Zhou

Abstract

Xeroderma pigmentosum group G (XPG) protein plays an important role in the DNA repair process by cutting the damaged DNA at the 3' terminus. Previous studies have indicated some polymorphisms in the XPG gene are associated with stomach cancer susceptibility. We performed this hospital-based case-control study to evaluate the association of four potentially functional XPG polymorphisms (rs2094258 C>T, rs751402 C>T, rs2296147 T>C and rs873601G>A) with stomach cancer susceptibility. The four single nucleotide polymorphisms (SNPs) were genotyped in 692 stomach cancer cases and 771 healthy controls. Logistic regression analysis was conducted, and odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the association of interest. Of the studied SNPs, XPG rs873601G>A polymorphism was found to significantly associate with stomach cancer susceptibility (AA versus OR = 1.31, 95% CI = 1.03-1.66, P = 0.027). Combined analysis of all SNPs revealed that the individuals with two of risk genotypes had a significantly increased stomach cancer risk (OR = 1.52, 95% CI = 1.13-2.06). In the stratification analysis, the association between the rs873601AA genotype and stomach cancer risk was observed in older group (>59 year), as we...Continue Reading

References

Apr 1, 1992·Gut·C Holcombe
Dec 23, 1994·Science·P C Hanawalt
Jun 20, 1997·The Journal of Biological Chemistry·M WakasugiA Sancar
Feb 5, 1998·Journal of the National Cancer Institute·W H ChowJ F Fraumeni
Feb 22, 2001·Science·R D WoodT Lindahl
Apr 24, 2001·Environmental and Molecular Mutagenesis·A Ronen, B W Glickman
May 9, 2001·Mutation Research·P C Hanawalt
Mar 20, 2002·Nature Reviews. Cancer·E C Friedberg
Dec 18, 2002·The Journal of Biological Chemistry·Jin-Sam YouSuk-Hee Lee
Jan 24, 2003·Nature·Errol C Friedberg
Feb 19, 2003·Journal of Clinical Epidemiology·Jon R Kelley, John M Duggan
Jan 17, 2004·Biochimie·S G Clarkson
Sep 30, 2004·International Journal of Cancer. Journal International Du Cancer·Gina D TranPhilip R Taylor
Aug 8, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Shehnaz K HussainZuo-Feng Zhang
Jan 1, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Wan-Guang YangXie-Fu Zhang
Sep 26, 2013·Nature Reviews. Clinical Oncology·Roopma WadhwaJaffer A Ajani
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal

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Citations

Nov 18, 2017·The International Journal of Biological Markers·Jun LiangQing-Rong Xia
Aug 24, 2017·Genetic Testing and Molecular Biomarkers·Yanyan SuZongxiang Zhang
Sep 29, 2019·World Journal of Gastroenterology : WJG·Xiao-Qin WangMing-Xu Wang
May 8, 2018·Journal of Clinical Laboratory Analysis·Zhe ZhangJianfeng Shi
Jan 5, 2021·British Journal of Biomedical Science·L YuanL Zeng
Apr 29, 2021·Cancer Management and Research·WeiLing YuSha Xiao

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Methods Mentioned

BETA
PCR
genotyping

Software Mentioned

SAS
GLOBOCAN

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