Association between YAP expression in neoplastic and non-neoplastic breast tissue with arsenic urinary levels.

Journal of Applied Toxicology : JAT
Gladis Michel-RamirezTania Gonzalez-Cortes

Abstract

The Hippo pathway regulates cell proliferation and apoptosis and it has been noted that loss of critical components of this pathway can lead to uncontrolled cell growth. Yes-associated protein (YAP) is an important component of this Hippo pathway because YAP is the nuclear effector of the Hippo tumor suppressor pathway and it is crucial for the response to oxidative stress induced by cellular process and by different xenobiotics, including arsenic. It has been proposed that YAP dysregulation can contribute to a malignant cellular phenotype acting as both a tumor suppressor and an oncogene. The aim of the study was to assess and compare the expression of YAP in neoplastic and non-neoplastic breast tissue of women chronically exposed to arsenic through drinking water. YAP expression was assessed by immunohistochemistry in 120 breast biopsies from women with breast cancer and from women with other non-neoplastic breast pathologies. Arsenic concentration was quantified in urine. The results disclosed a significant lower percentage of cytoplasm YAP expression in cases and that YAP high-intensity staining in the cytoplasm but not in the nucleus decreases the risk for breast cancer. In conclusion, our overall data suggest that YAP may...Continue Reading

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Citations

Oct 22, 2019·Journal of Applied Toxicology : JAT·Gladis Michel-RamirezMary Kay Amistadi
Jan 1, 2021·Frontiers in Public Health·Jessica De LomaKarin Broberg
Jan 29, 2021·Scientific Reports·Arun KumarAshok Kumar Ghosh
Jul 6, 2021·Reviews on Environmental Health·Roxana MoslehiDavid O Carpenter
Jan 10, 2020·The Science of the Total Environment·Khalid M KhanFaruque Parvez

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