Association Between Zolpidem and Suicide: A Nationwide Population-Based Case-Control Study

Mayo Clinic Proceedings
Yu SunChia-Hung Kao

Abstract

To evaluate the association between zolpidem and the risk of suicide. In this nationwide case-control study, the case group comprised 2199 people who committed suicide or were hospitalized due to suicide attempt between January 1, 2002, and December 31, 2011. To create a control group, we randomly selected 10 people matched to each case according to age, sex, urbanization, and occupation. We measured the risk of suicide/suicide attempt in association with zolpidem exposure by using adjusted odds ratios (ORs) and assessed the dose-response effect of zolpidem. After adjustment for potential confounders such as the comorbidities of schizophrenia, major depression, bipolar disorder, anxiety, insomnia, substance use, and other mental disorders, the Charlson comorbidity index, and use of benzodiazepine or antidepressants, zolpidem exposure was found to be significantly associated with the risk of suicide/suicide attempt with an OR of 2.08 (95% CIs, 1.83-2.36). The risk increased with the level of zolpidem use. The ORs (95% CIs) for cumulative defined daily doses of less than 90, 90 to 179, and 180 mg or more were 1.90 (1.65-2.18), 2.07 (1.59-2.67), and 2.81 (2.33-3.38), respectively (for trend, P<.001). Subgroup analyses showed that ...Continue Reading

References

Dec 17, 1997·Journal of Analytical Toxicology·M Lichtenwalner, R Tully
Nov 26, 1999·European Psychiatry : the Journal of the Association of European Psychiatrists·P SakkasG N Christodoulou
Apr 12, 2003·Journal of Psychopharmacology·I A LiappasG N Christodoulou
May 22, 2003·Health Affairs·Jui-Fen Rachel Lu, William C Hsiao
Aug 23, 2007·BMC Psychiatry·Daniel F Kripke
Aug 13, 2010·Journal of Affective Disorders·Charles B SchafferThomas E Nordahl
Sep 28, 2010·The Journal of Clinical Psychiatry·Kirk J BrowerMarcia Valenstein
Mar 8, 2011·Expert Review of Neurotherapeutics·Chi-Un PaePrakash S Masand
Mar 1, 2012·BMJ Open·Daniel F KripkeLawrence E Kline
Mar 27, 2012·Journal of Forensic Sciences·Shane DarkeJohan Duflou
Jul 17, 2012·Addictive Behaviors·Jason A Ford, James McCutcheon
Oct 23, 2012·The American Journal on Addictions·Alex S KeuroghlianRoger D Weiss
Dec 24, 2013·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Sameh Mortaz HejriMohammad Babaeian
Apr 29, 2014·International Journal of Legal Medicine·Alexander PaulkeStefan W Toennes
May 29, 2014·Developmental Medicine and Child Neurology·I-Ching ChouChia-Hung Kao
Jul 12, 2014·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Maryam Pourshams, Seyed Kazem Malakouti

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Citations

Aug 21, 2016·Current Psychiatry Reports·Leonardo Tondo, Ross J Baldessarini
Aug 20, 2016·Journal of Clinical Pharmacology·Fan-Gen HsuShih-Wei Lai
Feb 7, 2017·Archives of Suicide Research : Official Journal of the International Academy for Suicide Research·Tony BensonBrendan Bunting
Sep 7, 2017·Journal of Sleep Research·Dieter RiemannKai Spiegelhalder
Mar 19, 2019·Suicide & Life-threatening Behavior·BongKyoo ChoiJu-Young Shin
Dec 14, 2019·The Journal of Nervous and Mental Disease·Joseph Westermeyer, Tegan M Carr
Dec 19, 2017·The Health Care Manager·Minsoo Jung
Feb 9, 2019·Journal of Cellular and Molecular Medicine·Hong FangAnwen Shao
Oct 30, 2020·Archives of Suicide Research : Official Journal of the International Academy for Suicide Research·Eun KimDuk Hee Lee
Feb 10, 2021·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Andrew S TubbsMichael A Grandner
Jun 3, 2021·International Journal of Environmental Research and Public Health·Bo-Ram YangYoung-Mi Ah

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