Association of -344/T/C aldosterone synthase polymorphism (CYP11B2) with left ventricular structure and humoral parameters in young normotensive men

Blood Pressure
Samuel HellerMichael Aschermann

Abstract

Aldosterone plays an important role in development of left ventricular (LV) hypertrophy and myocardial fibrosis. We assessed the influence of the T-344C polymorphism of aldosterone synthase - the rate-limiting enzyme in aldosterone biosynthesis - on the structure of the left ventricle in young normotensive men. The population included 113 normotensive mid-European Caucasian men aged 18-40 years (mean 27 +/- 5 years). The genotype was assessed using polymerase chain reaction with subsequent cleavage with restriction enzyme HAEIII (restriction fragment length polymorphism method) and visualization with ethidium bromide. Plasma renin activity (PRA) and plasma aldosterone were measured. All subjects were examined by echocardiography and LV mass was assessed by using M-mode based ASE formula. The distribution of the genotypes was TT 23%:TC 55%:CC 22%. There were no differences in blood pressure among the groups. Men with the TT genotype had significantly higher levels of PRA (2.7 +/- 1.7 vs 1.8 +/- 1.0 vs 1.8 +/- 1.1 ng/ml/h, p < 0.01) and slightly higher plasma levels of aldosterone (113 +/- 64 vs 93 +/- 43 vs 87 +/- 39 pg/ml, p = 0,12). In the whole population, LV mass index (LVMI) did not differ significantly among the genotypes ...Continue Reading

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Citations

Jul 11, 2006·Pharmacology & Therapeutics·Reem H Elbekai, Ayman O S El-Kadi
Jul 10, 2012·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Iwona GorącyAndrzej Ciechanowicz
Dec 5, 2006·Journal of Hypertension·Silvia SookoianCarlos Jose Pirola
Sep 12, 2014·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Lijuan WangShaojun Wen

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