Association of β-blocker use with survival and pulmonary function in patients with chronic obstructive pulmonary and cardiovascular disease: a systematic review and meta-analysis.

European Heart Journal
Yan-Li YangRuo-Lan Xiang

Abstract

The aim of this study was to clarify the effect of β-blockers (BBs) on respiratory function and survival in patients with chronic obstructive pulmonary disease with cardiovascular disease (CVD), as well as the difference between the effects of cardioselective and noncardioselective BBs. We searched for relevant literature in four electronic databases, namely, PubMed, EMBASE, Cochrane Library, and Web of Science, and compared the differences in various survival indicators between patients with chronic obstructive pulmonary disease taking BBs and those not taking BBs. Forty-nine studies were included, with a total sample size of 670 594. Among these, 12 studies were randomized controlled trials (RCTs; seven crossover and five parallel RCTs) and 37 studies were observational (including four post hoc analyses of data from RCTs). The hazard ratios (HRs) of chronic obstructive pulmonary disease exacerbation between patients with chronic obstructive pulmonary disease who were not treated with BBs and those who were treated with BBs, cardioselective BBs, and noncardioselective BBs were 0.77 [95% confidence interval (CI) 0.67, 0.89], 0.72 [95% CI 0.56, 0.94], and 0.98 [95% CI 0.71, 1.34, respectively] (HRs <1 indicate favouring BB thera...Continue Reading

References

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Citations

Dec 15, 2020·European Heart Journal·Roberto FerrariGianluca Campo
Jan 29, 2021·Archives of Gerontology and Geriatrics·Erkin Saeed SaifiMaria L Muiesan
Mar 23, 2021·Respirology : Official Journal of the Asian Pacific Society of Respirology·Martin I MacDonald, Philip G Bardin
Aug 2, 2021·European Heart Journal·Giulio Francesco RomitiUNKNOWN AF-COMET International Collaborative Group
Sep 2, 2021·International Journal of Chronic Obstructive Pulmonary Disease·Mathias DamkjærKjell E J Håkansson
Sep 28, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Pierachille SantusDejan Radovanovic

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