Abstract
The aim of this study was to clarify the effect of β-blockers (BBs) on respiratory function and survival in patients with chronic obstructive pulmonary disease with cardiovascular disease (CVD), as well as the difference between the effects of cardioselective and noncardioselective BBs. We searched for relevant literature in four electronic databases, namely, PubMed, EMBASE, Cochrane Library, and Web of Science, and compared the differences in various survival indicators between patients with chronic obstructive pulmonary disease taking BBs and those not taking BBs. Forty-nine studies were included, with a total sample size of 670 594. Among these, 12 studies were randomized controlled trials (RCTs; seven crossover and five parallel RCTs) and 37 studies were observational (including four post hoc analyses of data from RCTs). The hazard ratios (HRs) of chronic obstructive pulmonary disease exacerbation between patients with chronic obstructive pulmonary disease who were not treated with BBs and those who were treated with BBs, cardioselective BBs, and noncardioselective BBs were 0.77 [95% confidence interval (CI) 0.67, 0.89], 0.72 [95% CI 0.56, 0.94], and 0.98 [95% CI 0.71, 1.34, respectively] (HRs <1 indicate favouring BB thera...Continue Reading
References
Jul 11, 2000·Journal of Molecular and Cellular Cardiology·S Dunzendorfer, C J Wiedermann
Dec 20, 2000·Thorax·M RolandJ A Wedzicha
Mar 26, 2003·Circulation·Don D Sin, S F Paul Man
Aug 11, 2007·Pulmonary Pharmacology & Therapeutics·Rui LinRichard A Bond
Aug 21, 2007·Pulmonary Pharmacology & Therapeutics·Nicola A HananiaRichard A Bond
Dec 22, 2007·American Journal of Respiratory Cell and Molecular Biology·Long P NguyenRichard A Bond
Nov 18, 2008·Medicine·John P HanrahanJoel Morganroth
Jul 23, 2009·BMJ : British Medical Journal·Alessandro LiberatiDavid Moher
Jul 9, 2013·European Heart Journal·Nathaniel M HawkinsClaudio Ceconi
Oct 10, 2013·The Journal of Clinical Hypertension·Deborah S MinorKenneth R Butler
Nov 27, 2014·PloS One·Qingxia DuYing Chen
Jul 26, 2015·The Lancet. Respiratory Medicine·Wenjia ChenJ Mark FitzGerald
Sep 1, 2015·European Heart Journal·Marco RoffiUNKNOWN ESC Scientific Document Group
Jul 9, 2016·The European Respiratory Journal·Brian LipworthMark T Dransfield
Nov 25, 2016·Pakistan Journal of Medical Sciences·Yuanyuan KeYongpeng Huang
Sep 10, 2017·European Heart Journal·Borja IbanezUNKNOWN ESC Scientific Document Group
Nov 22, 2017·European Journal of Heart Failure·Maurizio SessaChristian Torp-Pedersen
Mar 25, 2018·Internal Medicine Journal·Logan KratzerJeremy P Wrobel
Oct 22, 2019·The New England Journal of Medicine·Mark T DransfieldUNKNOWN BLOCK COPD Trial Group
Nov 18, 2019·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Albert J OmlorUNKNOWN German COSYCONET Cohort
Citations
Dec 15, 2020·European Heart Journal·Roberto FerrariGianluca Campo
Jan 27, 2021·European Heart Journal·Hui TangJin-Ling Tang
Jan 29, 2021·Archives of Gerontology and Geriatrics·Erkin Saeed SaifiMaria L Muiesan
Feb 1, 2021·European Heart Journal·Yan-Li YangRuo-Lan Xiang
Dec 23, 2020·European Heart Journal·Filippo Crea
Feb 25, 2021·Respiratory Research·Claudia GuleaJennifer K Quint
Mar 13, 2021·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Rutao WangPatrick W Serruys
Mar 22, 2021·European Heart Journal·Filippo Crea
Mar 23, 2021·Respirology : Official Journal of the Asian Pacific Society of Respirology·Martin I MacDonald, Philip G Bardin
May 6, 2021·European Heart Journal·Yan-Li YangRuo-Lan Xiang
May 6, 2021·European Heart Journal·Claudia GuleaRosita Zakeri
May 24, 2021·BMC Veterinary Research·Ali HatefiFrederic Pio
Aug 2, 2021·European Heart Journal·Giulio Francesco RomitiUNKNOWN AF-COMET International Collaborative Group
Sep 2, 2021·International Journal of Chronic Obstructive Pulmonary Disease·Mathias DamkjærKjell E J Håkansson
Sep 28, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Pierachille SantusDejan Radovanovic