Association of 11q loss, trisomy 12, and possible 16q loss with loss of imprinting of insulin-like growth factor-II in Wilms tumor

Genes, Chromosomes & Cancer
Naoki WatanabeY Kaneko

Abstract

We evaluated the WT1 and IGF2 status and performed chromosome and/or comparative genomic hybridization analysis in 43 tumor samples from patients with Wilms tumor. On this basis, we classified them into 4 groups: WT1 abnormality, loss of heterozygosity (LOH) of IGF2, loss of imprinting (LOI) of IGF2, and retention of imprinting (ROI) of IGF2, which were seen in 12%, 30%, 16%, and 42% of the tumors, respectively. Patients in the LOI group were older than those in other groups (P < 0.01), and tumors in the WT1 group had fewer cytogenetic changes than did those in the other groups (P < 0.01). It was found that 11q- and +12 were more frequent in the LOI group than in the WT1+LOH+ROI group (P < 0.01 and P < 0.01). There was no difference in the incidence of 16q- between the LOI group and the other groups; however, when we excluded 16 tumors with LOH on 11p15, 16q- tended to be more frequent in the LOI group than in the WT1+ROI group (P = 0.06). The association of 11q- or +12 with LOI of IGF2 found in the present study suggests that many tumors with no WT1 abnormalities need overexpression of IGF2 together with biallelic inactivation of the tumor-suppressor gene on 11q and/or overexpression of growth-promoting genes on chromosome 12....Continue Reading

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Citations

Aug 25, 2009·Pediatric Surgery International·Takaharu OueUNKNOWN Japan Wilms Tumor Study (JWiTS) Group
Sep 21, 2010·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Christopher BlackmoreAru Narendran
Aug 10, 2007·Journal of the National Cancer Institute·Hans T BjornssonAndrew P Feinberg
Sep 7, 2007·Journal of Pediatric Hematology/oncology·Ryuji Fukuzawa, Anthony E Reeve
Dec 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Raisa VuononvirtaChris Jones
Aug 19, 2011·Cytogenetic and Genome Research·L R CavalliB R Haddad
Apr 26, 2011·Pathology·Reena Md ZinAdrian Charles
Jul 31, 2010·Paediatric and Perinatal Epidemiology·Anna ChuRayjean J Hung
Oct 18, 2012·Genes, Chromosomes & Cancer·Jackie L LudgateIan M Morison
Aug 30, 2008·Molecular Biology and Evolution·Saverio VicarioJeffrey R Powell
Jul 23, 2008·Molecular Cancer Research : MCR·Keith W BrownKarim T A Malik

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