Association of 6-thioguanine nucleotide levels and inflammatory bowel disease activity: a meta-analysis

Gastroenterology
Mark T OstermanJames D Lewis

Abstract

6-Thioguanine nucleotide (6-TGN) levels have been proposed to correlate with inflammatory bowel disease (IBD) activity among patients treated with azathioprine or 6-mercaptopurine (6-MP). Previous studies, most with small sample sizes, yielded conflicting conclusions. Our aim was to pool the available data to provide a more precise estimate of the association between 6-TGN levels and IBD activity. We searched Medline and PubMed (from 1966 to November 2004) and reviewed the reference lists of selected articles. Fixed and random-effects models were used to test whether mean/median 6-TGN levels differed among patients with active disease vs remission and whether 6-TGN levels above a threshold of 230-260 pmol/8 x 10(8) red blood cells were associated with clinical remission. When studies reported multiple 6-TGN threshold values, we used the data for the lower value. We identified 55 articles, 12 of which contained data sufficient for inclusion. The mean/median 6-TGN levels were higher among patients in remission than in those with active IBD (pooled difference, 66 pmol/8 x 10(8) red blood cells; 95% confidence interval, 18-113; P = .006), but with significant heterogeneity. Excluding the 1 outlier study eliminated this heterogeneit...Continue Reading

References

Jan 1, 1992·European Journal of Clinical Pharmacology·L Lennard
May 1, 1985·Journal of Clinical Immunology·M BroganS Targan
Nov 17, 2004·Scandinavian Journal of Gastroenterology·U HindorfK Schmiegelow
Dec 4, 2015·Gastroenterology·Franck CarbonnelUNKNOWN Groupe d'Étude Thérapeutique des Affections Inflammatoires Digestives

❮ Previous
Next ❯

Citations

Jun 15, 2010·Nucleosides, Nucleotides & Nucleic Acids·S Almer
Jun 15, 2010·Nucleosides, Nucleotides & Nucleic Acids·S VikingssonC Peterson
Oct 12, 2010·Digestive Diseases·Peter D R Higgins
Mar 20, 2008·World Journal of Gastroenterology : WJG·Tsung-Chieh ShihCheng-Tang Chiu
Nov 11, 2011·World Journal of Gastroenterology : WJG·Kara Bradford, David Q Shih
Mar 8, 2013·World Journal of Gastroenterology : WJG·Pascal FreiGerhard Rogler
Dec 17, 2008·Expert Review of Gastroenterology & Hepatology·Imke Atreya, Markus F Neurath
Dec 17, 2008·Expert Review of Gastroenterology & Hepatology·Andrew B Grossman, Robert N Baldassano
May 4, 2013·Expert Review of Gastroenterology & Hepatology·Makoto NaganumaToshifumi Hibi
Aug 30, 2013·Expert Review of Gastroenterology & Hepatology·Ashwin N Ananthakrishnan
Sep 2, 2008·Expert Opinion on Drug Safety·Rupert Wl LeongMiles P Sparrow
Oct 6, 2010·Expert Opinion on Drug Metabolism & Toxicology·Pal Miheller, Peter Laszlo Lakatos
Nov 4, 2006·Alimentary Pharmacology & Therapeutics·K R Herrlinger, D P Jewell
May 15, 2015·Journal of Crohn's & Colitis·Shi Sum PoonSreedhar Subramanian
May 31, 2016·Expert Opinion on Pharmacotherapy·María Chaparro, Javier P Gisbert
Nov 5, 2016·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Fernando Bermejo San JoséAntonio López Sanromán
Aug 29, 2007·Clinics in Liver Disease·Sidharth S Bhardwaj, Naga Chalasani
Sep 4, 2007·The American Journal of Gastroenterology·Nanne K H de BoerAdriaan A van Bodegraven
Jul 22, 2014·Journal of Clinical Pharmacy and Therapeutics·S WeilerN Corti
Mar 24, 2017·Journal of Crohn's & Colitis·Akbar K WaljeePeter D R Higgins
Feb 6, 2017·Current Treatment Options in Gastroenterology·Gerassimos J Mantzaris
Jul 6, 2017·Expert Review of Clinical Immunology·Robin J Dart, Peter M Irving
Dec 25, 2010·Therapeutic Advances in Gastroenterology·Amar R Deshpande, María T Abreu
Jul 2, 2016·Therapeutic Advances in Gastroenterology·M Anthony Sofia, David T Rubin
Dec 12, 2017·Alimentary Pharmacology & Therapeutics·B Meijer, N K H de Boer
Oct 21, 2016·Inflammatory Bowel Diseases·Christian MottetPierre Michetti
Oct 16, 2010·Inflammatory Bowel Diseases·Jean-Baptiste ChevauxMiles P Sparrow
Nov 26, 2010·Inflammatory Bowel Diseases·Stephen B HanauerBruce E Sands
Jun 5, 2007·Inflammatory Bowel Diseases·Laurence J Egan
May 19, 2012·Inflammatory Bowel Diseases·Frank HoentjenAdriaan A van Bodegraven
Sep 12, 2015·Inflammatory Bowel Diseases·Danya J Rosen, Marla C Dubinsky
Sep 12, 2015·Inflammatory Bowel Diseases·Margot L Herman, Sunanda V Kane

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.