Association of a BACE1 Gene Polymorphism with Parkinson's Disease in a Norwegian Population

Parkinson's Disease
Johannes LangeJodi Maple-Grødem

Abstract

Background. Parkinson's disease (PD) and Alzheimer's disease (AD) share pathological features, including amyloid-beta pathology. Amyloid-beta peptide is generated by sequential proteolysis of amyloid precursor protein (APP), and genetic variations in the processing pathway genes have been found to increase the risk of AD; however, the contribution in PD is unknown. Methods. The aim of this study was to investigate whether candidate polymorphisms in five genes (ADAM10, BACE1, BACE2, PSEN2, and CLU) involved in the APP processing pathway affect PD risk in a population-based cohort of patients with incident PD and control subjects from the Norwegian ParkWest study. Results. We found an association of rs638405 in BACE1 with increased risk of PD, thus providing a novel link, at the genetic level, between amyloid-beta pathology and PD.

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Citations

May 25, 2018·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Kristin Aaser LundeJodi Maple-Grødem
Mar 16, 2018·Frontiers in Neurology·Aleksander H ErgaJodi Maple-Grødem
Aug 13, 2021·Frontiers in Aging Neuroscience·Annamaria VallelungaMaria Teresa Pellecchia
Mar 26, 2021·Current Alzheimer Research·Xu TangZhiyong Zhang

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Methods Mentioned

BETA
genotyping
PCR

Software Mentioned

SPSS
SNPStats
SPSS Statistics
ParkWest
Sequence Detection System

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