Association of a CAG/CAA repeat sequence in the TBP gene with type I diabetes

Biochemical and Biophysical Research Communications
D OwerbachKenneth H Gabbay

Abstract

Type I diabetes is a complex disease in which multiple susceptibility loci have been implicated by whole genome scans. IDDM8, a susceptibility locus, is located on chromosome 6q27, however the specific susceptibility gene has yet to be identified. We have examined five potential candidate genes using 36 genetic markers, spanning 360kb located near the chromosome 6q27 terminus in 478 families for diabetes association. No associations with type I diabetes susceptibility were detected with the strength previously observed for IDDM1 or IDDM2. However, a novel CAG/CAA polymorphism was detected in exon 3 of the TATA box-binding protein gene, which shows preliminary evidence of association with diabetes susceptibility (p<0.05).

References

Aug 11, 1991·Nucleic Acids Research·M H PolymeropoulosC R Merril
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Citations

Jan 20, 2007·BMC Genomics·Ondrej MiholaZdenek Trachtulec
Jun 20, 2013·Genesis : the Journal of Genetics and Development·Umair KhanGirish S Ratnaparkhi
Apr 27, 2005·Biochemical and Biophysical Research Communications·Felicity PayneRebecca C J Twells

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