Association of a functional single-nucleotide polymorphism in the ALDH2 gene with essential hypertension depends on drinking behavior in a Chinese Han population
Abstract
Alcohol consumption is an important environmental factor in the development of essential hypertension (EH) and cardiovascular disease. Several epidemiological studies have investigated the association between hypertension and acetaldehyde dehydrogenase 2 (ALDH2) genotype, although the results are inconsistent. The aim of the present study was to evaluate the possible effect of drinking behavior on the ALDH2-EH relationship in a Chinese Han population. A total of 1098 unrelated individuals with EH and 1021 controls of Chinese Han ethnicity were included. We evaluated the effect of three tag single-nucleotide polymorphisms on blood pressure (BP) and serum lipid level by blood chemical assays. The major findings were that rs671 guanine/adenine genotype (odds ratio (OR)=0.45, 95% confidence interval (CI): 0.28-0.74) and A allele (OR=0.55, 95% CI: 0.36-0.85) were associated with a decreased risk of EH in drinkers. In addition, the rs671 genotype influenced BP, triglyceride (TG) level and high-density lipoprotein cholesterol (HDL-C) level in the same drinking-dependent pattern. Drinkers who carried the A allele displayed lower systolic BP (β=-0.16, P=0.001) and TG level (β=-0.14, P=0.004) and higher HDL-C level (β=0.11, P=0.019), but...Continue Reading
References
Alcohol consumption and the incidence of hypertension: The Atherosclerosis Risk in Communities Study
Genetic differences in ethanol metabolizing enzymes and blood pressure in Japanese alcohol consumers
Citations
Impaired cardiac SIRT1 activity by carbonyl stress contributes to aging-related ischemic intolerance
Gene-environment interactions related to blood pressure traits in two community-based Korean cohorts
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