Association of a functional single-nucleotide polymorphism in the ALDH2 gene with essential hypertension depends on drinking behavior in a Chinese Han population

Journal of Human Hypertension
Y WangD Zhu

Abstract

Alcohol consumption is an important environmental factor in the development of essential hypertension (EH) and cardiovascular disease. Several epidemiological studies have investigated the association between hypertension and acetaldehyde dehydrogenase 2 (ALDH2) genotype, although the results are inconsistent. The aim of the present study was to evaluate the possible effect of drinking behavior on the ALDH2-EH relationship in a Chinese Han population. A total of 1098 unrelated individuals with EH and 1021 controls of Chinese Han ethnicity were included. We evaluated the effect of three tag single-nucleotide polymorphisms on blood pressure (BP) and serum lipid level by blood chemical assays. The major findings were that rs671 guanine/adenine genotype (odds ratio (OR)=0.45, 95% confidence interval (CI): 0.28-0.74) and A allele (OR=0.55, 95% CI: 0.36-0.85) were associated with a decreased risk of EH in drinkers. In addition, the rs671 genotype influenced BP, triglyceride (TG) level and high-density lipoprotein cholesterol (HDL-C) level in the same drinking-dependent pattern. Drinkers who carried the A allele displayed lower systolic BP (β=-0.16, P=0.001) and TG level (β=-0.14, P=0.004) and higher HDL-C level (β=0.11, P=0.019), but...Continue Reading

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Citations

Mar 26, 2013·Basic Research in Cardiology·Hussain ContractorRajesh K Kharbanda
Jun 17, 2014·Alcoholism, Clinical and Experimental Research·Akiko MatsumotoMasayoshi Ichiba
Sep 30, 2014·The Tohoku Journal of Experimental Medicine·Feng XuYuguo Chen
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Oct 8, 2016·Environmental Health and Preventive Medicine·Akiko MatsumotoVasilis Vasiliou
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Feb 2, 2018·Nihon eiseigaku zasshi. Japanese journal of hygiene·Akiko Matsumoto
Jun 15, 2017·Clinical and Experimental Hypertension : CHE·Zhan-Ming LiLi-Shun Wang
Nov 8, 2019·Expert Opinion on Therapeutic Targets·Mitsuru KimuraSusumu Higuchi
May 1, 2020·International Heart Journal·Xiao-Fei MeiTan Chen

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