Association of a p73 exon 2 GC/AT polymorphism with colorectal cancer risk and survival in Tunisian patients.

Virchows Archiv : an International Journal of Pathology
Amira Toumi ArfaouiSadaa Bouraoui

Abstract

We examined the association of one linked GC/AT polymorphism at p73 with the risk of colorectal cancer. In the present study, we investigated whether this polymorphism was related to the risk of colorectal cancer, and whether there were relationships between the polymorphism and LOH, protein expression or clinicopathological variables. The p73 genotypes were determined by PCR-restriction fragment length polymorphism in 150 Tunisians patients with colorectal cancer and in 204 healthy control subjects. Immunohistochemistry was performed on normal mucosa, primary tumour and metastasis. The frequencies of the genotypes were 52% for wild-type (GC/GC), 31% for heterozygotes (GC/AT) and 17% for variants (AT/AT) in patients, and 54%, 35% and 11% in controls, respectively. There were no significant differences of the frequencies of the three genotypes between the patients and controls (p = 0.11). We did not find any relationship of the genotypes with clinicopathological features of patients. We found that patients with the AT/AT genotype had a significantly worse clinical outcome than those with the GC/AT and GC/GC genotype. There were no significant differences between tumoural immunostaining of the total p73 and p73 polymorphism (p = ...Continue Reading

References

Oct 31, 1998·International Journal of Cancer. Journal International Du Cancer·Y NimuraA Nakagawara
Mar 8, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N I HerathG A Macdonald
Apr 13, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·L ShanK Kakudo
Dec 26, 2001·Cell Death and Differentiation·T J GrobA Tobler
Feb 5, 2002·Biochimica Et Biophysica Acta·U M MollA Zaika
Feb 15, 2002·The Journal of Biological Chemistry·Thorsten StieweBrigitte M Pützer
Aug 3, 2002·Nature Reviews. Cancer·Gerry MelinoKaren H Vousden
Mar 6, 2003·Human Mutation·Jean BénardJean-Charles Ahomadegbe
Jul 17, 2003·Japanese Journal of Clinical Oncology·Ming GuanYuan Lu
Nov 25, 2003·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Xin-En HuangKazuo Tajima
Dec 9, 2003·Trends in Biochemical Sciences·Gerry MelinoRichard A Knight
Oct 7, 2004·Cancer Research·Guojun LiQingyi Wei
Oct 16, 2004·Carcinogenesis·Daniella PfeiferXiao-Feng Sun
Apr 29, 2006·Cell Death and Differentiation·B Fernandez-GarciaM C Marín
Oct 18, 2006·The Journal of Pathology·P J Coates
Jul 8, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jasmine LööfXiao-Feng Sun

❮ Previous
Next ❯

Citations

Jul 17, 2010·Journal of Gastrointestinal Cancer·Luciana Zaia PoveglianoNora Manoukian Forones
Mar 1, 2012·Journal of Cancer Research and Clinical Oncology·Ling XieRun-Zhou Ni
Aug 7, 2014·Prostate Cancer·L Michael CarastroJong Y Park
Mar 5, 2021·Frontiers in Oncology·Solomon O RotimiBodour Salhia

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.