Association of a placental Interleukin-6 genetic variant (rs1800796) with DNA methylation, gene expression and risk of acute chorioamnionitis

BMC Medical Genetics
Chaini KonwarWendy P Robinson

Abstract

Acute chorioamnionitis (aCA), inflammation of the placenta and fetal membranes, is a frequently reported lesion in preterm deliveries. Genetic variants in innate immune system genes such as Interleukin-6 (IL6) may contribute to the placenta's inflammatory response, thus predisposing some pregnancies to aCA. These genetic variants may modulate molecular processes such as DNA methylation and gene expression, and in turn might affect susceptibility to aCA. Currently, there is remarkably little research on the role of fetal (placental) genetic variation in aCA. We aimed to explore the associations between genetic variants in candidate immune-system genes and susceptibility towards inflammatory responses in the placenta, which is linked to a strong inflammatory response in the newborn. DNA samples from 269 placentas (72 aCA cases, 197 non-aCA cases) were collected for this study. Samples were genotyped at 55 ancestry informative markers (AIMs) and 16 additional single nucleotide polymorphisms (SNPs) in 12 candidate innate immune system genes using the Sequenom iPLEX Gold Assay. Publicly available datasets were used to obtain DNA methylation (GSE100197, GSE74738, GSE115508, GSE44667, GSE98224) and gene expression data (GSE44711, GSE9...Continue Reading

References

May 1, 1990·Placenta·T KamedaO Tanizawa
Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Nov 1, 1986·American Journal of Public Health·P H Shiono, M A Klebanoff
Apr 16, 1998·American Journal of Obstetrics and Gynecology·K D WenstromS P Cliver
Mar 3, 2001·American Journal of Obstetrics and Gynecology·A R GoepfertUNKNOWN National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network
Mar 20, 2001·JAMA : the Journal of the American Medical Association·A KochP Garred
Jun 9, 2001·The Journal of Clinical Endocrinology and Metabolism·D F BenyoK P Conrad
Aug 3, 2001·Pediatrics·M S KramerUNKNOWN Fetal/Infant Health Study Group of the Canadian Perinatal Surveillance System
May 8, 2002·American Journal of Epidemiology·Maroeska RoversRobert Plomin
Sep 6, 2002·Genetic Epidemiology·Liselotte PetersenThorkild I A Sørensen
Sep 19, 2003·Trends in Microbiology·Shelley Segal, Adrian V S Hill
Oct 31, 2003·American Journal of Obstetrics and Gynecology·Hyagriv N SimhanSteve N Caritis
Jan 8, 2004·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Raymond W RedlineUNKNOWN Society for Pediatric Pathology, Perinatal Section, Amniotic Fluid Infection Nosology Committee
Mar 18, 2004·Journal of Periodontology·Lydie Izakovicova HollaJiri Vacha
Jul 2, 2004·Nature Reviews. Immunology·Shizuo Akira, Kiyoshi Takeda
May 6, 2006·The Journal of Allergy and Clinical Immunology·Tsuneyasu Kaisho, Shizuo Akira
May 25, 2006·Bioinformatics·Xavier SoléVíctor Moreno
Jul 19, 2006·American Journal of Obstetrics and Gynecology·Robert L GoldenbergJohn C Hauth
Oct 13, 2006·The American Journal of Gastroenterology·Lars C SteneMarian Rewers
Oct 27, 2006·Investigative Ophthalmology & Visual Science·Emma B H HumeMark D P Willcox
Dec 6, 2006·Human Immunology·Esther Monika SpeerDavid Peter Skoner
Jun 15, 2007·Maternal and Child Health Journal·Emile Papiernik
Aug 2, 2007·Pediatric Research·Tannette G KredietGer T Rijkers
Dec 1, 2007·American Journal of Epidemiology·Allen J WilcoxRolv Terje Lie
Feb 5, 2008·Nature Genetics·Luis B BarreiroLluís Quintana-Murci
Feb 9, 2008·Arthritis Research & Therapy·Olli-Pekka KämäräinenPäivi Leino-Arjas
Jun 24, 2008·The Journal of Pediatrics·Milla ReimanUNKNOWN PIPARI Study Group
Jul 2, 2008·Obstetrics and Gynecology·Katherine P Himes, Hyagriv N Simhan
Jul 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ceri A FieldingBrendan J Jenkins
Dec 17, 2008·Forensic Science International. Genetics·C PhillipsUNKNOWN SNPforID Consortium
Sep 12, 2009·Nucleic Acids Research·Mario DandreaMarta Palmieri
Oct 27, 2009·American Journal of Epidemiology·Anna C SvenssonPaul Lichtenstein
Feb 12, 2010·The New England Journal of Medicine·Louis J Muglia, Michael Katz
Apr 30, 2010·Bulletin of the World Health Organization·Stacy BeckPaul F A Van Look
May 14, 2010·Pediatric Research·Asmaa Abu-MaziadJeffrey C Murray
Sep 10, 2010·Infectious Diseases in Obstetrics and Gynecology·Jessica E ThaxtonSurendra Sharma
Nov 9, 2010·BJOG : an International Journal of Obstetrics and Gynaecology·M R Genc, A Onderdonk

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Citations

Sep 27, 2019·Human Genetics·Giulia F Del GobboWendy P Robinson
Dec 8, 2020·Frontiers in Immunology·Jeffery A GoldsteinAlison D Gernand
Jun 3, 2021·International Journal of Environmental Research and Public Health·Aurélie NakamuraJohanna Lepeule

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Datasets Mentioned

BETA
GSE74738
GSE44711
GSE44667
GSE98224

Methods Mentioned

BETA
genotyping
MDS

Software Mentioned

R sva package
R
R minfi package

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