Association of a polymorphism of the ecNOS gene with myocardial infarction in a subgroup of Turkish MI patients

Clinical Genetics
N CineN Erginel-Unaltuna

Abstract

In this study we examined a possible association between a 27 base pair (bp)-repeat polymorphism in intron 4 of the ecNOS gene and myocardial infarction (MI) in a subgroup of the Turkish population. We compared MI and control groups for the frequencies of the ecNOS alleles and their genotypes. The frequency of the ecNOS 4a/a and 4a/b genotypes was found to be significantly higher in the MI group than in the control group. Interestingly, the frequency of the ecNOS 4a/b polymorphism was found to be significantly higher in the selected MI group (patients with no known secondary risk factors) than in the control and non-selected MI group. We found that the patients with MI had the frequency of the a/a genotype 4.3%, of the a/b genotype 26.6% and the b/b genotype 69.1%. The controls, however, showed only 0.6% for a/a, 18.0% for a/b and 81.4% for the b/b genotype (P < 0.001; chi2 = 13.626). In this study, we show that myocardial infarction is associated with one subtype of ecNOS gene polymorphism.

References

Jul 1, 1992·Acta Physiologica Scandinavica·S Moncada
Oct 1, 1988·The American Journal of Cardiology·L B Jorde, R R Williams
Dec 30, 1993·The New England Journal of Medicine·S Moncada, A Higgs
Feb 15, 1994·Biochemical and Biophysical Research Communications·S NadaudF Soubrier
Aug 1, 1994·European Journal of Biochemistry·K MiyaharaY Doi
Sep 23, 1994·Cell·C Nathan, Q W Xie
May 1, 1995·Journal of Vascular Research·G J Dusting
Apr 14, 1994·The New England Journal of Medicine·M E MarenbergU de Faire

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Citations

Mar 4, 2015·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Jana WobstHeribert Schunkert
Oct 5, 2006·American Journal of Epidemiology·Juan P CasasAroon D Hingorani
Mar 17, 2012·Molecular Biology Reports·Alfredo SantovitoMassimiliano Delpero
Feb 12, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Xiang-Zhen KongJing Yu

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