Association of a rare variant of the TNFSF13B gene with susceptibility to Rheumatoid Arthritis and Systemic Lupus Erythematosus

Scientific Reports
David González-SernaJavier Martin

Abstract

A rare variant (BAFF-var) of the tumor necrosis factor superfamily 13b (TNFSF13B) gene has been recently associated with multiple sclerosis (MS) and systemic lupus erythematosus (SLE). The aim of this study was to investigate the association between TNFSF13B BAFF-var and susceptibility to rheumatoid arthritis (RA) and replicate that association in SLE. 6,218 RA patients, 2,575 SLE patients and 4,403 healthy controls from three different countries were included in the study. TNFSF13B BAFF-var was genotyped using TaqMan allelic discrimination assay. PLINK software was used for statistical analyses. TNFSF13B BAFF-var was significantly associated with RA (p = 0.015, OR = 1.21, 95% CI = 1.03-1.41) in the Spanish cohort. A trend of association was observed in the Dutch (p = 0.115) and German (p = 0.228) RA cohorts. A meta-analysis of the three RA cohorts included in this study revealed a statistically significant association (p = 0.002, OR = 1.24, 95% CI = 1.10-1.38). In addition, TNFSF13B BAFF-var was significantly associated with SLE in the Spanish (p = 0.001, OR = 1.41, 95% CI = 1.14-1.74) and the German cohorts (p = 0.030, OR = 1.86, 95% CI = 1.05-3.28), with a statistically significant p-value obtained in the meta-analysis (p = ...Continue Reading

References

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Citations

Jun 13, 2019·Journal of Clinical Medicine·Marialbert Acosta-HerreraJavier Martín
Apr 22, 2020·Immunology and Cell Biology·Simon H JiangCarola G Vinuesa
Sep 10, 2020·Expert Opinion on Therapeutic Targets·Roberta MagliozziMassimiliano Calabrese
Nov 23, 2019·BMC Nephrology·Justa Friebus-KardashCornelia Hardt
Nov 10, 2020·QJM : Monthly Journal of the Association of Physicians·Jui-Hung Chen, Charles Tzu-Chi Lee
Jun 3, 2021·Scientific Reports·Diana Prieto-PeñaRaquel López-Mejías

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Methods Mentioned

BETA
PCR

Software Mentioned

Power Calculator for Genetic Studies 2006 ( CaTS )
PLINK

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