PMID: 8583138Nov 1, 1995Paper

Association of a restriction fragment length polymorphism in the alcohol dehydrogenase 2 gene with Japanese alcoholic liver cirrhosis

Journal of Hepatology
M YamauchiS Sakurai

Abstract

The association of ADH2 polymorphisms with alcoholic liver cirrhosis has not been clearly demonstrated. We investigated the association of two alleles in the ADH2 gene marked by restriction fragment length polymorphisms in patients with alcoholic liver cirrhosis. The ADH2 restriction fragment polymorphisms with Mae III were determined using the polymerase chain reaction on lymphocytes from 76 male Japanese alcoholics (non-cirrhotic patients; 34 cases, cirrhotic patients; 42 cases) and 60 healthy male subjects. The frequency of the ADH2(1)/ADH2(1) genotype was significantly higher in the alcoholics than in the healthy subjects p < 0.001). In the alcoholics, the genotype ADH2(2)/ADH2(2) was significantly more prevalent in the cirrhotic group than in the non-cirrhotic group (p < 0.05). These results suggest that the Mae III polymorphisms of the ADH2 gene may be associated not only with susceptibility to alcoholic liver cirrhosis, but also with the development of alcoholism in Japanese patients.

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Citations

Oct 30, 2001·Journal of Hepatology·S Bellentani, C Tiribelli
Aug 28, 2007·Alcohol Research & Health : the Journal of the National Institute on Alcohol Abuse and Alcoholism·Howard J Edenberg
Jul 1, 2000·Addiction Biology·S BellentaniC Tiribelli
Nov 1, 1996·Alcoholism, Clinical and Experimental Research·D W Crabb, H J Edenberg
Jan 28, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Elias ZintzarasFrancesc Vidal
Mar 14, 2008·Alcoholism, Clinical and Experimental Research·Eric Nguyen-KhacMickaël Naassila
Jan 16, 1999·Baillière's Clinical Gastroenterology·M F Bassendine, C P Day
Mar 18, 2015·Journal of Gastroenterology and Hepatology·Hiroshi AbeYoshio Aizawa
May 28, 2004·International Journal of Toxicology·Darryl P ArfstenChristopher A Loffredo
Mar 25, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E BorràsX Parés
Oct 19, 2004·European Journal of Gastroenterology & Hepatology·Stefano BellentaniClaudio Tiribelli
Feb 24, 2006·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Felix Stickel, Christoph H Osterreicher
Sep 8, 2011·Alcoholism, Clinical and Experimental Research·Jesús García-BañuelosBlanca Estela Bastidas-Ramírez

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