Association of a single-nucleotide polymorphism in low-density lipoprotein receptor-related protein 5 gene with bone mineral density

Journal of Bone and Mineral Metabolism
Tomohiko UranoS Inoue

Abstract

Low-density lipoprotein receptor-related protein 5 (LRP5) is an important regulator of osteoblast growth and differentiation, affecting peak bone mass in vertebrates. Here, we analyzed whether the LRP5 gene was involved in the etiology of postmenopausal osteoporosis, using association analysis between bone mineral density (BMD) and an LRP5 gene single-nucleotide polymorphism (SNP). Association of an SNP in the LRP5 gene at IVS17-1677C > A (intron 17) with BMD was examined in 308 postmenopausal Japanese women (65.2 +/- 9.6 years; mean +/- SD). The subjects bearing at least one variant A allele (CA + AA; n = 142) had significantly lower Z scores for total body and lumbar BMD than the subjects with no A allele (CC; n = 166) (total body, 0.08 +/- 1.09 versus 0.50 +/- 1.03; P = 0.0022; lumbar spine, -0.42 +/- 1.43 versus -0.02 +/- 1.42; P = 0.013). These findings suggest that the LRP5 gene is a candidate for the genetic determinants of BMD in postmenopausal women, and this SNP could be useful as a genetic marker for predicting the risk of osteoporosis.

Citations

Mar 20, 2008·JAMA : the Journal of the American Medical Association·Joyce B J van MeursUNKNOWN GENOMOS Study
Mar 8, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J YamaguchiN Hamajima
May 17, 2007·Calcified Tissue International·M Audrey KoayMatthew A Brown
Mar 12, 2009·Journal of Bone and Mineral Metabolism·Tomohiko UranoSatoshi Inoue
Aug 11, 2010·Journal of Bone and Mineral Metabolism·Takayuki Hosoi
May 25, 2007·Current Osteoporosis Reports·Roland Baron, Georges Rawadi
Apr 7, 2005·Molecular Aspects of Medicine·Serge L Ferrari, R Rizzoli
Aug 27, 2011·Expert Reviews in Molecular Medicine·Hou-Feng ZhengJ Brent Richards
Feb 10, 2010·BMC Genetics·Jiangxia LiYaoqin Gong
Jun 3, 2014·BMC Musculoskeletal Disorders·Rim SassiSerge Livio Ferrari
Mar 13, 2014·Current Osteoporosis Reports·Hiromu Ito
Dec 1, 2010·Aging Clinical and Experimental Research·Fulvio LauretaniLuigi Ferrucci
Nov 15, 2011·Gene·David G MonroeJennifer J Westendorf
Apr 14, 2015·Endocrine Journal·Tomohiko Urano, Satoshi Inoue
Aug 26, 2009·Geriatrics & Gerontology International·Tomohiko UranoSatoshi Inoue
Jan 24, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Dong-Hai XiongHong-Wen Deng
Mar 1, 2007·Journal of Neurochemistry·Kaihong Mi, Gail V W Johnson
Dec 16, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Joyce B J van MeursAndré G Uitterlinden
Sep 26, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yong-Jun LiuHong-Wen Deng
Apr 19, 2012·American Journal of Medical Genetics. Part a·Christine M LaineEtienne Sochett
Jun 10, 2006·Molecular Genetics and Metabolism·Qing-Yang Huang, Annie Wai Chee Kung
Sep 28, 2005·Expert Opinion on Therapeutic Targets·Georges Rawadi, Sergio Roman-Roman
Aug 21, 2014·Biochemical and Biophysical Research Communications·Tomohiko Urano, Satoshi Inoue
Jun 16, 2005·Current Opinion in Rheumatology·Stuart H Ralston
May 1, 2010·Endocrine Reviews·Stuart H Ralston, André G Uitterlinden
May 1, 2007·The Proceedings of the Nutrition Society·Stuart H Ralston

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