Association of a vascular endothelial growth factor gene 936 C/T polymorphism with breast cancer risk: a meta-analysis

Breast Cancer Research and Treatment
Dae Sik YangJae Hong Seo

Abstract

Published studies on the association between the vascular endothelial growth factor (VEGF) gene 936 C/T polymorphism and breast cancer risk are inconclusive, and a meta-analysis is required to verify the association. Nine studies, including a total of 4,973 cases and 5,035 controls, were subjected to meta-analysis. When all eligible subjects were pooled for meta-analysis, the CT + TT genotypes were not associated with a significant decrease in breast cancer risk (odds ratio = 0.87; 95% confidence interval 0.75-1.02; P = 0.087). We also categorized by ethnicity (Caucasian, Asian, or mixed) for subgroup analysis, however, according to this subgroup analysis, we found no significant association between the CT and TT versus CC genotype with breast cancer risk reduction in any of the subgroups. We conclude that the VEGF gene 936 C/T polymorphism does not affect breast cancer risk.

References

Oct 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D MaglioneM G Persico
Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Nov 18, 1971·The New England Journal of Medicine·J Folkman
Jan 20, 1995·The Journal of Biological Chemistry·G L Wang, G L Semenza
May 1, 1997·Nature Medicine·J W UhrE S Vitetta
Oct 31, 1998·Current Opinion in Genetics & Development·G L Semenza
Sep 23, 2000·Nature·P Carmeliet, R K Jain
Jul 8, 2003·International Journal of Cancer. Journal International Du Cancer·Peter KripplHellmut Samonigg
Feb 27, 2004·Nature·Judah Folkman, Raghu Kalluri
Jul 22, 2004·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·K C SmithW M Howell
Nov 13, 2004·Breast Cancer Research : BCR·Freddie BrayD Maxwell Parkin
May 18, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Qianren JinAsta Försti
Jun 16, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Nobuhiko KataokaWei Zheng
May 2, 2007·International Journal of Cancer. Journal International Du Cancer·Sabapathy P BalasubramanianMalcolm W Reed
Sep 25, 2007·Breast Cancer Research and Treatment·Bryan P SchneiderDavid A Flockhart
Sep 12, 2008·Breast Cancer Research and Treatment·Bryan P SchneiderGeorge W Sledge
Feb 7, 2009·Omics : a Journal of Integrative Biology·Gau-Tyan LinHsueh-Wei Chang

❮ Previous
Next ❯

Citations

Oct 29, 2010·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Cristiane OliveiraCarmen S P Lima
Dec 2, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Alicia Beeghly-FadielWei Zheng
Dec 4, 2012·International Journal of Molecular Sciences·Doonyapat Sa-Nguanraksa, Pornchai O-Charoenrat
Jan 7, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yulan YanXue Qin
Jun 4, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Ting LuoHong Zheng
Sep 28, 2017·Brain and Behavior·Silvia VeganzonesGregorio Rodríguez-Boto

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Breast Cancer: Chemo-Resistance

Some cancers are difficult to treat and aggressive including the "triple-negative" breast cancer. This type of cancer is chemoresistant even before chemotherapy begins. Here are the latest discoveries chemo-resistance in breast cancer.