Association of ABCB1 C3435T polymorphism with the susceptibility to osteonecrosis of the femoral head: A meta-analysis

Medicine
Yu ZhangQingyu Meng

Abstract

The exploration for the etiology of osteonecrosis of the femoral head (ONFH) has got some promising findings, but the morbidity of ONFH is still not under control. The C3435T polymorphism of ATP-binding cassette subfamily B member 1 (ABCB1) gene has been reported to possess significant influence on ONFH onset, but relevant outcomes remain conflicting rather than conclusive. Therefore, a meta-analysis was useful to pool these results together for a more reliable conclusion. The association of ABCB1 C3435T polymorphism with ONFH susceptibility was estimated through calculated odds ratios (ORs) with their 95% confidence intervals (95% CIs). The Q-test was applied for detecting inter-study heterogeneity, whereas sensitivity analysis for identifying any study owning substantial influence on pooled results. Begg's funnel plot and Egger's test were employed to examine publication bias across included studies. ABCB1 C3435T polymorphism significantly decreased the risk of ONFH under TT vs CC (OR = 0.26, 95% CI = 0.13-0.50), TT+CT vs CC (OR = 0.72, 95% CI = 0.52-0.99), TT vs CC+CT (OR = 0.28, 95% CI = 0.15-0.52), and T vs C (OR = 0.64, 95% CI = 0.50-0.81) contrasts. The variant C3435T in the ABCB1 gene may offer protection against the at...Continue Reading

References

May 28, 1992·The New England Journal of Medicine·H J Mankin
Mar 1, 1995·The Journal of Bone and Joint Surgery. American Volume·M A Mont, D S Hungerford
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Feb 6, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Caryn G MorseJoseph A Kovacs
Jun 9, 2007·European Journal of Radiology·Konstantinos N MalizosThomas Maris
Jun 29, 2007·The American Journal of Chinese Medicine·Jianzhu LiuDuck-Hwan Kim
Aug 13, 2008·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Masaaki KuribayashiToshikazu Kubo
Aug 19, 2008·Therapeutic Drug Monitoring·Arzu GunesMaria Gabriella Scordo
Feb 7, 2009·Parkinsonism & Related Disorders·Marie WesterlundDagmar Galter
Mar 19, 2009·HSS Journal : the Musculoskeletal Journal of Hospital for Special Surgery·Thomas W HamiltonMark Figgie
May 12, 2009·The Journal of Steroid Biochemistry and Molecular Biology·Mohammad Amin KerachianEdward J Harvey
Mar 13, 2010·Clinical Orthopaedics and Related Research·Wakaba FukushimaYoshio Hirota
Sep 17, 2010·The Journal of Bone and Joint Surgery. American Volume·Michael A MontRonald E Delanois
Nov 26, 2010·Journal of Pediatric Orthopedics·Annalise Noelle LarsonDavid G Lewallen
Oct 20, 2011·Pharmacogenomics·Kerry Reed, Amadeo M Parissenti
Apr 16, 2014·Clinical Rheumatology·Eugène MutijimaJean-Philippe Hauzeur

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.