Association of abdominal muscle composition with prediabetes and diabetes: The CARDIA study

Diabetes, Obesity & Metabolism
Andrea GranadosJoyce M Lee

Abstract

To evaluate the relationship of abdominal muscle lean tissue and adipose tissue volumes with prediabetes and diabetes. We measured abdominal muscle composition in 3170 participants in the Coronary Artery Risk Development in Young Adults (CARDIA) study who underwent computed tomography (CT) at Year 25 of follow-up (ages, 43-55 years). Multinomial regression analysis was used to evaluate the associations of CT-measured intermuscular adipose tissue (IMAT), lean muscle tissue (lean) and visceral adipose tissue (VAT) volumes with diabetes at any point during the CARDIA study, newly detected prediabetes, prior history of prediabetes, and normal glucose tolerance. Models were adjusted for potential confounding factors: age, sex, race, height, smoking status, hypertension, hyperlipidaemia, cardiorespiratory fitness and study centre. Higher IMAT, lean and VAT volumes were all separately associated with a higher prevalence of prediabetes and diabetes. Inclusion of VAT volume in models with both IMAT volume and lean volume attenuated the association of IMAT with both prediabetes and diabetes, but higher lean volume retained its association with prediabetes and diabetes. Individuals in the highest IMAT quartile, coupled with VAT in its low...Continue Reading

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Citations

Mar 12, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·Amin CheikhiAaron Barchowsky
May 21, 2019·Journal of Cellular Physiology·Daniele FerraraFederico Carbone
Mar 12, 2020·Frontiers in Cardiovascular Medicine·Alan Chait, Laura J den Hartigh
Nov 28, 2020·Journal of Cachexia, Sarcopenia and Muscle·Maxime NachitIsabelle Anne Leclercq
Jul 11, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Katherine M BunnellMiriam A Bredella
Aug 7, 2021·Diabetes & Metabolism Journal·Iva MiljkovicMatthew Allison
Sep 28, 2021·Scandinavian Journal of Medicine & Science in Sports·María MedranoIdoia Labayen
Nov 21, 2021·Diabetes/metabolism Research and Reviews·Eun Hee KimJaewon Choe
Jan 16, 2022·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Yesenia García-AlonsoRobinson Ramírez-Vélez

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