Association of absence of intestinal oxalate degrading bacteria with urinary calcium oxalate stone formation

International Journal of Urology : Official Journal of the Japanese Urological Association
Kazuo MikamiHaruo Ito

Abstract

Urinary concentration of oxalate is considered an important factor in the formation of renal stones. Dietary oxalate is a major contributor to urinary oxalate excretion in most individuals. Furthermore, oxalate degrading bacteria have been isolated from human feces. We investigated the significance of oxalate degrading bacteria for urinary oxalate excretion and urinary stone formation. Twenty-two known calcium oxalate stone-forming patients (stone formers) and 34 healthy volunteers (non-stone formers) were included in the study. Stool specimens were inoculated into pepton yeast glucose (PYG) medium supplemented with oxalate under anaerobic condition at 37 C for one week. After the incubation period, each colony was checked for the loss of oxalate from the culture medium. A 24-h urine sample was collected in 43 individuals and analyzed for oxalate excretion. Twenty-eight of 34 (82%) healthy volunteers and 10 of 22 (45%) calcium oxalate stone formers were colonized with oxalate degrading bacteria. Calcium oxalate stone formers were more frequently free of oxalate degrading bacteria (P < 0.01). Urinary excretion of oxalate in those with oxalate degrading bacteria was significantly less than in those without oxalate degrading bacte...Continue Reading

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Citations

Jun 29, 2004·Urological Research·Ross P Holmes, Dean G Assimos
Nov 27, 2004·Urological Research·Marguerite Hatch, Robert W Freel
Aug 7, 2007·The Urologic Clinics of North America·Sangtae Park, Margaret S Pearle
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Mar 25, 2008·Seminars in Nephrology·Marguerite Hatch, Robert W Freel
Jun 30, 2005·International Journal of Urology : Official Journal of the Japanese Urological Association·Sanehiro HokamaYoshihide Ogawa
Jul 14, 2012·Journal of Applied Microbiology·J S GnanandarajahM P Murtaugh
Jun 30, 2004·Veterinary Microbiology·J S WeeseJ Rousseau
Aug 27, 2015·American Journal of Veterinary Research·Jenny G ChoJody P Lulich
Jun 1, 2007·Journal of the American Society of Nephrology : JASN·Eric N Taylor, Gary C Curhan
Oct 16, 2016·Journal of the American Society of Nephrology : JASN·Donna ArvansHatim Hassan
Mar 9, 2018·Advances in Urology·Tilahun Alelign, Beyene Petros
Jul 14, 2021·Journal of Endourology·Mantu GuptaWilliam Atallah

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