Association of Acute Increase in Plasma Neurofilament Light with Repetitive Subconcussive Head Impacts: A Pilot Randomized Control Trial

Journal of Neurotrauma
Angela WirschingKeisuke Kawata

Abstract

The purpose of the study was to examine an association of repetitive subconcussive head impacts with changes in plasma neurofilament light (NF-L) levels following 10 bouts of controlled soccer heading. In this randomized control trial, 37 healthy adult soccer players were randomly assigned into either a heading (n = 19) or kicking-control group (n = 18). The heading group executed 10 headers with soccer balls projected at a velocity of 25 mph over 10 min. Plasma samples were obtained at pre-heading baseline, 0 h, 2 h, and 24 h post-heading. The kicking-control group followed the same protocol with 10 kicks. Plasma NF-L was measured using ultrasensitive single-molecule array technology. Data from 34 subjects were eligible for analysis (heading n = 18 and kicking n = 16). Ten subconcussive head impacts induced a gradual increase in plasma NF-L expression for the heading group (β = 0.0297, standard error [SE] = 0.01, p = 0.0049), whereas there was no significant time effect for the kicking-control group. A follow-up analysis revealed that a significant difference appeared at 24 h post-heading (3.68 ± 0.30 pg/mL) compared with pre-heading (3.12 ± 0.29 pg/mL, p = 0.0013; Cohen's d = 1.898). At the 24 h post-heading time-point, the p...Continue Reading

Associated Clinical Trials

References

Jan 18, 2005·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Stefan M DumaJoseph J Crisco
May 15, 2007·British Journal of Sports Medicine·Henrik ZetterbergKaj Blennow
Nov 11, 2010·Journal of Athletic Training·Joseph J CriscoRichard M Greenwald
Nov 9, 2012·Medicine and Science in Sports and Exercise·Jonathan G BeckwithMichael W Collins
Dec 5, 2012·Brain : a Journal of Neurology·Ann C McKeeRobert C Cantu
Aug 27, 2013·Journal of Neurosurgery·Julian E BailesThomas Talavage
Jul 11, 2014·Journal of Neurotrauma·Brian JohnsonSemyon Slobounov
Dec 5, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jeffrey J IliffMaiken Nedergaard
Jan 16, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Benjamin A PlogMaiken Nedergaard
Apr 9, 2015·Frontiers in Neurology·Gregory A ElderStephen T Ahlers
Dec 25, 2015·Journal of Neurotrauma·Jonathan OliverHenrik Zetterberg
Feb 10, 2016·International Journal of Sports Medicine·K KawataJ J Jeka
Feb 18, 2016·Journal of Neurotrauma·Sungjae HwangJohn J Jeka
May 18, 2016·Neuroscience and Biobehavioral Reviews·Keisuke KawataDianne Langford
Jun 4, 2016·JAMA Ophthalmology·Keisuke KawataDianne Langford
Aug 23, 2016·Journal of Gastroenterology and Hepatology·Kimihiro IgarashiHiroyuki Ono
Nov 8, 2016·Scientific Reports·Pashtun ShahimKaj Blennow
Feb 10, 2017·Journal of Neurotrauma·Keisuke KawataDianne Langford
Feb 23, 2017·Sports Health·Abigail C BretzinJane K McDevitt
Jul 26, 2017·JAMA : the Journal of the American Medical Association·Jesse MezAnn C McKee

❮ Previous
Next ❯

Citations

Nov 14, 2018·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Amit SinglaR Shane Tubbs
Jul 10, 2019·Frontiers in Sports and Active Living·Nicholas J CecchiDavid J Reinkensmeyer
May 19, 2021·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·Eleni KarantaliIoannis Mavroudis
Jul 30, 2021·Journal of Biomechanics·Tanner M FilbenJoel D Stitzel
Sep 29, 2021·Journal of the International Society of Sports Nutrition·Jeffery L HeilesonJonathan M Oliver

❮ Previous
Next ❯

Methods Mentioned

BETA
blood draw
enzyme-linked immunosorbent assay

Clinical Trials Mentioned

NCT03488381

Software Mentioned

[UNK]

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.