Association of ADH4 genetic variants with alcohol dependence risk and related phenotypes: results from a larger multicenter association study

Addiction Biology
Ulrich W PreussPeter Zill

Abstract

Genetic variants of the alcohol-metabolizing enzyme ADH4, located on chromosome 4q22-4q23, have been related to alcohol dependence (AD) risk in previous research. The aim of this association study in a large multicenter sample of alcohol-dependent individuals and controls is to confirm ADH4 single nucleotide polymorphism (SNP) and haplotype association with AD and relevant related phenotypes. One thousand, six hundred and twenty-two (1622) inpatient subjects and 1469 control subjects with DSM-IV. AD from four addiction treatment centres were included. Characteristics of AD and related phenotypes including alcohol withdrawal, Cloninger's type I and II and first ages of drinking, regular drinking and AD onset were obtained using standardized structured interviews. After subjects were genotyped for 2 ADH4 polymorphisms, single SNP case-control and haplotype analyses were conducted. Both variants--rs1800759 and rs1042364--and the A-A and C-G haplotypes were significantly related to AD across samples. Furthermore, associations with AD-related phenotypes and subtypes revealed a potential protective influence of this haplotype. This study confirms the significant relationship of ADH4 variants with AD and related phenotypes. While the ...Continue Reading

References

Oct 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·T K LiB L Vallee
Nov 1, 1988·Genetics·R C Lewontin
Aug 1, 1995·Alcoholism, Clinical and Experimental Research·J P RiceH Begleiter
Jun 1, 1994·Alcoholism, Clinical and Experimental Research·H R ThomassonS J Yin
May 29, 1998·American Journal of Medical Genetics·T ReichH Begleiter
Jan 1, 2000·Addiction·M HesselbrockV Hesselbrock
Aug 3, 2002·The American Journal of Psychiatry·Deborah HasinTing-Kai Li
Dec 10, 2003·Archives of General Psychiatry·Soo Hyun RheeMichael C Stallings
Mar 25, 2005·American Journal of Human Genetics·Janis E WiggintonGoncalo R Abecasis
May 3, 2005·The American Journal of Psychiatry·Camila GuindaliniMayana Zatz
Oct 21, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Xingguang LuoJoel Gelernter
Mar 31, 2006·Human Molecular Genetics·Howard J EdenbergTatiana Foroud
Feb 3, 2007·American Journal of Human Genetics·Ping-I LinEden R Martin
Aug 28, 2007·Alcohol Research & Health : the Journal of the National Institute on Alcohol Abuse and Alcoholism·Howard J Edenberg
Mar 6, 2008·American Journal of Human Genetics·Dmitri V Zaykin, Kyoko Shibata
Jul 8, 2009·Archives of General Psychiatry·Jens TreutleinMarcella Rietschel

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Citations

Apr 22, 2011·Psychiatry and Clinical Neurosciences·Mitsuru Kimura, Susumu Higuchi
Dec 7, 2013·World Journal of Gastroenterology : WJG·Sonia RomanArturo Panduro
Jun 4, 2011·Alcoholism, Clinical and Experimental Research·Ian R GizerCindy L Ehlers
Jan 22, 2015·Addiction Biology·Kora-Mareen BühlerJose Antonio López-Moreno
May 28, 2015·Scandinavian Journal of Psychology·Włodzimierz OniszczenkoJerzy Samochowiec
Dec 15, 2010·Alcoholism, Clinical and Experimental Research·Arpana AgrawalAndrew C Heath

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