Association of adiponectin gene variation with progression of nonalcoholic fatty liver disease: A 4-year follow-up survey

Journal of Digestive Diseases
Yong Jian ZhouYu Yuan Li

Abstract

To explore the role of tagging single nucleotide polymorphisms (tagSNPs) in the adiponectin gene in the natural course of nonalcoholic fatty liver disease (NAFLD). The participants were chosen from our previous survey containing 3543 individuals. Finally, a total of 696 participants who had been followed up for a median of 4 years were included. Each participant was administered with an interview, physical examination, blood tests and ultrasonic examination at both baseline and end-point. Polymerase chain reaction-restriction fragment length polymorphism was applied to determine seven tagSNPs in the adiponectin gene, namely, rs182052, rs16861205, rs822396, rs7627128, rs1501299, rs2241767 and rs3774261. Ordinal logistic regression was used to screen risk factors of NAFLD progression as well as the susceptibility to the disease. Haplotypes analyses were performed to confirm the results. After adjusting for age and gender, rs1501299 (G276T), rs2241767 (A45G) and rs3774261 (A712G) were found to be risk factors of both susceptibility (OR 5.040, 7.471 and 3.546, respectively) and progression (OR 3.83, 3.51 and 3.30, respectively) to NAFLD. Nevertheless, rs182052, rs16861205, rs822396 and rs7627128 had no impact on them. These finding...Continue Reading

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Citations

Jan 5, 2016·Metabolism: Clinical and Experimental·Stergios A PolyzosChristos S Mantzoros
Nov 20, 2016·Journal of Digestive Diseases·Wen Ji ChenYong Jian Zhou
Jan 19, 2017·Journal of Clinical Gastroenterology·Karn WijarnpreechaPatompong Ungprasert
Mar 29, 2018·Endocrinology and Metabolism·Chrysoula BoutariChristos Socrates Mantzoros

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