Association of adiponectin with blood pressure in healthy people

Clinical Endocrinology
M Y BadenYuji Matsuzawa

Abstract

With the increasing prevalence of diseases related to obesity, metabolic syndrome and its key player adiponectin are now attracting considerable attention. Hypoadiponectinaemia is reported to be a risk factor for hypertension and associated with endothelial dysfunction, which is closely related to complications of obesity such as hypertension. As there is limited information regarding serum adiponectin levels in normotensive people, we undertook the large-scale study to determine the association of adiponectin with blood pressure (BP) in mainly normotensive people. In 21 100 Japanese adults (12 363 men and 8737 women) who had no apparent diseases, we examined the relationship between the serum adiponectin concentration and BP by performing a questionnaire survey, physical measurements and measurement of laboratory parameters including the serum adiponectin level. Subjects with hypoadiponectinaemia had higher systolic and diastolic BPs as already reported. And interestingly, subjects with higher adiponectin had lower systolic and diastolic BP. According to linear regression analysis, adiponectin showed a significant negative correlation with systolic and diastolic BP independently of the other variables. Analysis of covariance a...Continue Reading

References

Jun 7, 2002·The Journal of Clinical Endocrinology and Metabolism·Miyao MatsubaraShinji Katayose
Jan 9, 2003·American Journal of Hypertension·Marcin AdamczakYuji Matsuzawa
Jan 28, 2003·Lancet·Joachim SprangerAndreas F H Pfeiffer
Mar 27, 2003·Journal of Hypertension·C M M LawesUNKNOWN Asia Pacific Cohort Studies Collaboration
Jul 5, 2003·The Journal of Clinical Endocrinology and Metabolism·Michio ShimabukuroYuji Matsuzawa
Jul 16, 2003·Hypertension·Noriyuki OuchiYuji Matsuzawa
Aug 29, 2003·The Journal of Biological Chemistry·Hui ChenMichael J Quon
Feb 7, 2004·The Journal of Clinical Endocrinology and Metabolism·K C B TanK S L Lam
May 5, 2004·Hypertension·Yoshio IwashimaToshio Ogihara
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Barry J Goldstein, Rosario Scalia
Sep 24, 2004·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Mercedes Gil-CamposAngel Gil
Feb 9, 2006·Clinical Science·Yoshihisa OkamotoPeter Libby
May 23, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ayako Nishimura, Tokio Sawai
Apr 30, 2008·Hypertension·Yoshitaka MurakamiUNKNOWN Evidence for Cardiovascular Prevention From Observational Cohorts in Japan Research Group (EPOCH-JAPAN)
Mar 21, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Toshio OgiharaUNKNOWN Japanese Society of Hypertension Committee
Dec 5, 2009·Clinical and Experimental Nephrology·UNKNOWN Japanese Society of Nephrology
Oct 6, 2010·Hypertension·John M FlackUNKNOWN International Society on Hypertension in Blacks
Dec 24, 2010·World Journal of Cardiology·Hanrui ZhangCuihua Zhang

❮ Previous
Next ❯

Citations

Dec 22, 2015·Journal of Diabetes and Metabolic Disorders·Gita ShafieeRamin Heshmat
Apr 17, 2016·International Journal of Cardiology·Salvatore Chirumbolo
Jun 13, 2015·International Journal of Endocrinology·C M GhantousA Zeidan
Apr 25, 2015·Advances in Chronic Kidney Disease·Akhilesh RaoAdam Whaley-Connell
Mar 29, 2016·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Chelsea L Deschamps, Dustin S Hittel
Aug 21, 2013·International Journal of Endocrinology·Kristina BlaslovLea Duvnjak
Jun 14, 2014·Current Hypertension Reports·Edward RojasManuel Velasco
Dec 25, 2013·Pediatrics·Satomi KoyamaOsamu Arisaka

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.