Association of advanced vasculopathy and transforming growth factor-beta1 gene expression with immunoglobulin A nephropathy progression

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Irena BrabcovaOndrej Viklicky

Abstract

The mechanism of IgA nephropathy (IgAN) progression remains ill-defined. In this prospective study, the prognostic role of clinical, histological and molecular markers over a 2-year follow-up was evaluated. Fifty-one patients with biopsy-proven IgAN were followed for 24 months. Besides routine histology, the intrarenal gene expressions of cytokines and chemokines were quantified by reverse transcription quantitative real-time polymerase chain reaction, and the presence of lymphocytes and macrophages were immunohistochemically examined. Higher transforming growth factor-β1 and severe chronic vasculopathy (but not glomerulosclerosis, interstitial fibrosis or lymphocyte infiltrate) were associated with the IgAN progression 24 months after biopsy. The gene expression of chemokine (C-C motif) ligands 2 and 5, hepatocyte growth factor, bone morphogenic protein-7 and transforming growth factor-β1 and the interstitial infiltrate of T and B lymphocytes and macrophages were significantly associated with serum creatinine and glomerular filtration rate at the time of biopsy. The intrarenal chemokine (C-C motif) ligand 2 and hepatocyte growth factor gene expression were associated with the proteinuria. Besides the known risk factors for chr...Continue Reading

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Citations

Dec 29, 2010·Clinical Reviews in Allergy & Immunology·Hsin-Hui YuBor-Luen Chiang
Sep 6, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Dita MaixnerovaVladimir Tesar
Feb 1, 2011·Clinical and Experimental Pharmacology & Physiology·Peter Boor, Jürgen Floege
Jun 22, 2011·Kidney & Blood Pressure Research·Petra Hribova, Ondrej Viklicky
Apr 20, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Maria Teresa RocchettiLoreto Gesualdo
Oct 26, 2018·Journal of Translational Medicine·M Cañadas-GarreA J McKnight

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