PMID: 11913765Mar 27, 2002Paper

Association of aflatoxin biosynthesis and sclerotial development in Aspergillus parasiticus

Mycopathologia
Perng-Kuang ChangPeter J Cotty

Abstract

Secondary metabolism in fungi is frequently associated with asexual and sexual development. Aspergillus parasiticus produces aflatoxins known to contaminate a variety of agricultural commodities. This strictly mitotic fungus. besides producing conidia asexually, produces sclerotia, structures resistant to harsh conditions and for propagation. Sclerotia are considered to be derived from the sexual structure, cleistothecia. and may represent a vestige of ascospore production. Introduction of the aflatoxin pathway-specific regulatory gene, aflR, and aflJ, which encoded a putative co-activator, into an O-methylsterigmatocystin (OMST)-accumulating strain, A. parasiticus SRRC 2043, resulted in elevated levels of accumulation of major aflatoxin precursors, including norsolorinic acid (NOR), averantin (AVN), versicolorin A (VERA) and OMST. The total amount of these aflatoxin precursors, NOR, VERA, AVN and OMST, produced by the aflR plus aflJ transformants was two to three-fold that produced by the aflR transformants. This increase indicated a synergistic effect of aflR and aflJ on the synthesis of aflatoxin precursors. Increased production of the aflatoxin precursors was associated with progressive decrease in sclerotial size, alterati...Continue Reading

Citations

Aug 6, 2004·Applied and Environmental Microbiology·Ana M CalvoNancy P Keller
Mar 5, 2005·Applied and Environmental Microbiology·Michael J MillerJohn E Linz
Aug 20, 2005·Journal of Applied Microbiology·K C EhrlichP J Cotty
Nov 16, 2011·Folia Microbiologica·Asghar SepahvandMehdi Razzaghi-Abyaneh
Mar 13, 2015·Frontiers in Microbiology·Ana M Calvo, Jeffrey W Cary
Feb 20, 2020·International Journal of Environmental Research and Public Health·Noreddine Benkerroum
Aug 1, 2007·Applied Microbiology and Biotechnology·Perng-Kuang ChangThomas E Cleveland
Mar 1, 2006·Mycotoxin Research·K C Ehrlich
Sep 14, 2007·Food Additives and Contaminants·Bruce W Horn
Apr 10, 2003·Eukaryotic Cell·Andrew V GreeneDeborah Bell-Pedersen
Sep 22, 2007·Food Additives and Contaminants·Jiujiang YuWilliam C Nierman
Apr 16, 2018·Fungal Genetics and Biology : FG & B·Opemipo Esther FasoyinShihua Wang
Oct 20, 2005·Journal of Bioscience and Bioengineering·Kazuhiro Iwashita
Jun 26, 2021·Frontiers in Microbiology·Xinhong PengXiliang Jiang
Aug 1, 2008·Fungal Genetics and Biology : FG & B·Shubha P KaleJin Woo Bok
Feb 28, 2006·Revista iberoamericana de micología·Jiujiang YuJoan W Bennett
Jul 28, 2010·Fungal Genetics and Biology : FG & B·Joseph Strauss, Yazmid Reyes-Dominguez

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