Association of alleles carried at TNFA -850 and BAT1 -22 with Alzheimer's disease.

Journal of Neuroinflammation
Anastazija GnjecRalph N Martins

Abstract

Inflammatory changes are a prominent feature of brains affected by Alzheimer's disease (AD). Activated glial cells release inflammatory cytokines which modulate the neurodegenerative process. These cytokines are encoded by genes representing several interleukins and TNFA, which are associated with AD. The gene coding for HLA-B associated transcript 1 (BAT1) lies adjacent to TNFA in the central major histocompatibility complex (MHC). BAT1, a member of the DEAD-box family of RNA helicases, appears to regulate the production of inflammatory cytokines associated with AD pathology. In the current study TNFA and BAT1 promoter polymorphisms were analysed in AD and control cases and BAT1 mRNA levels were investigated in brain tissue from AD and control cases. Genotyping was performed for polymorphisms at positions -850 and -308 in the proximal promoter of TNFA and position -22 in the promoter of BAT1. These were investigated singly or in haplotypic association in a cohort of Australian AD patients with AD stratified on the basis of their APOE epsilon4 genotype. Semi-quantitative RT-PCR was also performed for BAT1 from RNA isolated from brain tissue from AD and control cases. APOE epsilon4 was associated with an independent increase in ...Continue Reading

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Citations

Sep 22, 2011·Expert Reviews in Molecular Medicine·Judith Miklossy
Aug 29, 2012·Autism Research and Treatment·Anthony R TorresAllen J Rosenspire
Jul 22, 2015·Proceedings of the National Academy of Sciences of the United States of America·Mihwa SeoSeung-Jae V Lee
Jun 16, 2012·RNA Biology·Lenz Steimer, Dagmar Klostermeier
Oct 4, 2014·Ageing Research Reviews·Correne A DeCarloStuart W S MacDonald
Oct 16, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·Hee-Ju KangJin-Sang Yoon

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Methods Mentioned

BETA
genotyping
PCR
electrophoresis

Software Mentioned

SPSS
[UNK] run
Statistical Package for Social Sciences ( SPSS
Thesias

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