Association of allograft inflammatory factor-1 gene polymorphism with rheumatoid arthritis

Tissue Antigens
Andrzej PawlikMarek Drozdzik

Abstract

Human allograft inflammatory factor-1 (AIF-1) is a cytoplasmic protein primarily identified in human and rat allografts, and data from several studies suggest an important role for AIF-1 in inflammatory processes. The aim of this study was to examine the association between AIF1 rs2269475:C>T polymorphism and rheumatoid arthritis (RA). AIF1 genotype was determined by means of the polymerase chain reaction-restriction fragment length polymorphism method in 276 White patients with RA and 236 healthy subjects. The frequency of the AIF1 rs2269475 TT genotype was significantly higher in the patients with RA than in the controls (OR=5.59, 95% CI: 1.22-25.55). The frequency of T allele carriers in the patient group with RA was 31.9% vs 19.1% among controls (P=0.0003). Moreover, the frequency of individuals positive for anti-cyclic citrullinated peptide (anti-CCP) antibodies was significantly elevated in the T allele carriers (OR=8.82, 95% CI: 2.06-37.7). It is noteworthy that no significant linkage disequilibria between the AIF1 C/T and DRB1 alleles associated with RA development and anti-CCP antibody production [including the most frequent, i.e. *04 (32.7%) and *01 (23.5%)] (P>0.1) were found. Our results show that the AIF1 rs2269475...Continue Reading

References

Jun 9, 2001·Rheumatic Diseases Clinics of North America·I B McInnes
Sep 25, 2001·Lancet·D M Lee, M E Weinblatt
Apr 12, 2002·FEBS Letters·Martin H DeiningerHermann J Schluesener
Jan 1, 1994·Acta Crystallographica. Section D, Biological Crystallography·T C Terwilliger
Aug 13, 2005·Scandinavian Journal of Rheumatology·A PawlikM Herczynska
Feb 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mizuho KimuraToshikazu Yoshikawa

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Citations

Nov 24, 2011·Genetic Testing and Molecular Biomarkers·Andrzej PawlikBarbara Gawronska-Szklarz
Aug 29, 2012·Autism Research and Treatment·Anthony R TorresAllen J Rosenspire
Jul 28, 2012·Tissue Antigens·A Ruyssen-WitrandM Thomsen
Feb 23, 2017·Nature Communications·Sari KishikawaHiroshi Kiyono
Dec 13, 2019·Immunology Letters·Mateusz SikoraAndrzej Pawlik
Oct 30, 2020·Biology·Jacopo VizioliPatrizia Pagliara

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