Association of angiotensin-converting enzyme I gene I/D polymorphism with endometrial but not with ovarian cancer

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Silvana Aparecida Alves Correa-NoronhaIsmael Dale Cotrim Guerreiro da Silva

Abstract

Associations have been found between the angiotensin-converting enzyme insertion deletion (I/D) polymorphism (ACE I/D) and endometrial and epithelial ovarian cancer (EC and EOC, respectively). In this study, the following frequencies for each of three ACE polymorphisms, DD, ID, and II, respectively, were observed: in the EC group, 55, 24, and 21% versus the control group 39, 40, and 21% (p = 0.033*); in the EOC group 49, 36, and 15% versus the control group 49, 33, and 18% (p = 0.82). According to these allelic distributions, DD carriers are 2.0 times more likely than individuals carrying the ID or II genotypes to develop EC; therefore, the DD genotype seems to be protective against EC. In contrast, no association was observed between ACE (I/D) polymorphism with EOC. The ACE (I/D) polymorphism might play a role in the pathogenesis of EC and it should be considered when identifying genetic markers for EC.

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May 6, 2011·Medical Hypotheses·Soha NamaziHamed Abedtash

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Citations

Feb 20, 2015·Archives of Gynecology and Obstetrics·Fatma BeyazitTayfun Gungor
Jun 7, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Derick Okwan-DuoduRoberto Diaz
Jul 2, 2020·International Journal of Molecular Sciences·Kamila Domińska

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