Abstract
We determined the influence of angiotensin I-converting enzyme (ACE) insertion (I)/deletion (D) polymorphism on the extent of myocardial ischemia in patients with acute myocardial infarction. The I/D polymorphism, which in part controls plasma and tissue expression of ACE, has been implicated in predisposition to myocardial infarction and ventricular remodeling. I/D genotyping, predischarge adenosine-thallium-201 perfusion tomography and radionuclide angiography were performed in 113 patients (72 men, 41 women) with a diagnosis of acute myocardial infarction. A subgroup of 96 patients also underwent coronary angiography. Genotypes DD, ID and II were present in 27, 56 and 30 patients, respectively. There was no significant difference in the baseline characteristics of patients, total creatine kinase, peak MB fraction, Killip class, mean ejection fraction or the number of diseased vessels in patients with the DD, ID or II genotype. However, the size of the total and the reversible perfusion defects was greater in those with DD than in those with ID or II genotype (total defect size [mean +/- SD] 33.7 +/- 22.5%, 29.5 +/- 19.2% and 22.2 +/- 16.0%, respectively [p = 0.022]; reversible defect size 18.0 +/- 16.0%, 12.1 +/- 11.6% and 8...Continue Reading
References
Mar 25, 1992·Nucleic Acids Research·B RigatF Soubrier
Oct 15, 1992·Nature·F CambienS Ricard
Dec 1, 1992·British Journal of Pharmacology·W LinzB A Schölkens
Nov 14, 1992·Lancet·S YusufB Pitt
Sep 13, 1992·The New England Journal of Medicine·M A PfefferG C Flaker
Oct 1, 1990·The Journal of Clinical Investigation·B RigatF Soubrier
Aug 1, 1991·The New England Journal of Medicine·UNKNOWN SOLVD InvestigatorsJay N Cohn
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·F SoubrierP Corvol
Jul 14, 1988·The New England Journal of Medicine·M A PfefferE Braunwald
Jul 1, 1987·Circulation·J H ChesebroP Ludbrook
Aug 1, 1988·The Journal of Pediatrics·R F O'DeaA R Sinaiko
Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Sep 1, 1984·Journal of Cardiovascular Pharmacology·N SomeyaK Tanaka
Nov 15, 1995·Circulation·F PieruzziH R Keiser
Jan 1, 1995·Annual Review of Pharmacology and Toxicology·J V Mombouli, P M Vanhoutte
Aug 15, 1995·The American Journal of Cardiology·N OhmichiM Kinoshita
Sep 1, 1995·The Journal of Clinical Investigation·L S ZismanM V Raynolds
Sep 15, 1995·Circulation·A H DanserH Schunkert
Oct 1, 1995·Circulation·M LechinR Roberts
May 1, 1995·Journal of the American College of Cardiology·J J MahmarianM S Verani
May 11, 1995·Nature·J H KregeO Smithies
Jun 1, 1995·Journal of the American College of Cardiology·Y M PintoH Schunkert
Mar 1, 1995·The Journal of Clinical Investigation·D E VaughanK Tong
Oct 1, 1994·Circulation·E M LonnB Pitt
Oct 20, 1994·The New England Journal of Medicine·M OhishiT Ogihara
Aug 1, 1994·Circulation·F CambienG Luc
Oct 30, 1993·Lancet·A J MarianR Roberts
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·J RuizP Froguel
Jun 9, 1994·The New England Journal of Medicine·H SchunkertG A Riegger
Sep 1, 1993·Circulation Research·J Sadoshima, S Izumo
Apr 1, 1993·Circulation·H SchunkertB H Lorell
Jun 1, 1993·Circulation·K K GriendlingR W Alexander
Oct 1, 1996·Circulation·S HokimotoE Miyamoto
Citations
Sep 16, 1999·Clinical Cardiology·J NagashimaM Murayama
Aug 15, 2000·Clinical Cardiology·J NagashimaM Murayama
Jun 25, 2008·Journal of Thrombosis and Thrombolysis·Giuseppe PattiGermano Di Sciascio
Feb 20, 2003·Transplantation Proceedings·J ArayaN Watanabe
Apr 3, 1998·Journal of the American College of Cardiology·J L AndersonR H Ward
Sep 14, 1999·Journal of the American College of Cardiology·D HenrionB I Lévy
Jan 15, 2000·Journal of the American College of Cardiology·A J MarianC M Ballantyne
Mar 15, 2000·Journal of the American College of Cardiology·B ZhuW W Parmley
Jun 26, 2001·European Journal of Clinical Investigation·M CarluccioR De Caterina
Nov 11, 1999·Current Opinion in Lipidology·J P O'MalleyD R Illingworth
Jul 8, 2009·Pakistan Journal of Biological Sciences : PJBS·C SesalN Sayar
Aug 12, 2009·Thrombosis Research·Vicente BodiAngel Llacer
May 2, 2001·The American Journal of Medicine·R TabibiazarS G Rockson
Jan 23, 2014·Thrombosis Research·Lian GuGuihua Huang
Aug 27, 1999·European Heart Journal·M PfohlK R Karsch
Oct 27, 1999·Angiology·A OkamuraT Ogihara
Apr 15, 2003·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Bo-qing ZhuWilliam W Parmley
Sep 17, 2003·Circulation·William S Weintraub, Saihari Sadanandan
Apr 13, 2007·Coronary Artery Disease·Mehmet S UlgenNizamettin Toprak
Oct 22, 2019·Genetic Testing and Molecular Biomarkers·Yongtao ZhangJinzhao Liu
Jan 12, 2021·IJC Heart & Vasculature·Nagaraja MoorthyRita Christopher