PMID: 9180106Jun 1, 1997Paper

Association of angiotensin I-converting enzyme gene polymorphism with myocardial ischemia and patency of infarct-related artery in patients with acute myocardial infarction

Journal of the American College of Cardiology
H A DakikA J Marian

Abstract

We determined the influence of angiotensin I-converting enzyme (ACE) insertion (I)/deletion (D) polymorphism on the extent of myocardial ischemia in patients with acute myocardial infarction. The I/D polymorphism, which in part controls plasma and tissue expression of ACE, has been implicated in predisposition to myocardial infarction and ventricular remodeling. I/D genotyping, predischarge adenosine-thallium-201 perfusion tomography and radionuclide angiography were performed in 113 patients (72 men, 41 women) with a diagnosis of acute myocardial infarction. A subgroup of 96 patients also underwent coronary angiography. Genotypes DD, ID and II were present in 27, 56 and 30 patients, respectively. There was no significant difference in the baseline characteristics of patients, total creatine kinase, peak MB fraction, Killip class, mean ejection fraction or the number of diseased vessels in patients with the DD, ID or II genotype. However, the size of the total and the reversible perfusion defects was greater in those with DD than in those with ID or II genotype (total defect size [mean +/- SD] 33.7 +/- 22.5%, 29.5 +/- 19.2% and 22.2 +/- 16.0%, respectively [p = 0.022]; reversible defect size 18.0 +/- 16.0%, 12.1 +/- 11.6% and 8...Continue Reading

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Citations

Apr 3, 1998·Journal of the American College of Cardiology·J L AndersonR H Ward
Jun 26, 2001·European Journal of Clinical Investigation·M CarluccioR De Caterina
Nov 11, 1999·Current Opinion in Lipidology·J P O'MalleyD R Illingworth
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Apr 15, 2003·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Bo-qing ZhuWilliam W Parmley
Sep 17, 2003·Circulation·William S Weintraub, Saihari Sadanandan

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