Association of angiotensin II type 1 receptor-associated protein gene polymorphism with increased mortality in septic shock

Critical Care Medicine
Taka-aki NakadaKeith R Walley


Angiotensin II and its postreceptor signaling are crucial in regulating vasomotor tone. The objective of this study was to test the hypothesis that single nucleotide polymorphisms in angiotensin II pathway genes alter outcome of septic shock. Genetic association study and in vitro experiment. Intensive care units at academic teaching centers. Derivation and validation septic shock cohorts (n = 589 and n = 616, respectively) and a coronary artery bypass surgery cohort (n = 551). Patients with septic shock in the derivation cohort were genotyped for tag single nucleotide polymorphisms: angiotensin-converting enzyme (six single nucleotide polymorphisms), angiotensin II receptor type 1 (five single nucleotide polymorphisms), and angiotensin II type 1 receptor-associated protein (three single nucleotide polymorphisms), which is a negative regulator of angiotensin II receptor type 1. Patients in the septic shock replication cohort and the coronary artery bypass graft cohort were genotyped for the angiotensin II type 1 receptor-associated protein rs11121816. The primary outcome variable was 28-day mortality. Secondary outcome variables were blood pressure and heart rate. Angiotensin II type 1 receptor-associated protein messenger RNA ...Continue Reading


Jan 20, 2000·The New England Journal of Medicine·UNKNOWN Heart Outcomes Prevention Evaluation Study InvestigatorsG Dagenais
Apr 21, 2001·Biometrics·B Devlin, K Roeder
Aug 18, 2001·Hypertension·M BucherA Kurtz
Oct 20, 2001·Cell Research·D F GuoT Inagami
Dec 6, 2001·The International Journal of Biochemistry & Cell Biology·Wei WangYumin Mao
Feb 22, 2002·Theoretical Population Biology·B DevlinL Wasserman
Sep 3, 2002·American Journal of Respiratory and Critical Care Medicine·Richard P MarshallGeoffrey J Laurent
Dec 19, 2003·American Journal of Human Genetics·Christopher S CarlsonDeborah A Nickerson
Jul 13, 2004·The New England Journal of Medicine·Robert W Schrier, Wei Wang
Dec 6, 2005·Journal of the American College of Cardiology·Mihai V Podgoreanu, Debra A Schwinn
May 13, 2006·Circulation Research·F A Sayed-TabatabaeiJ C M Witteman
Jul 28, 2006·American Journal of Physiology. Cell Physiology·Puja K Mehta, Kathy K Griendling
Sep 20, 2006·Nature Reviews. Genetics·David J Balding
Nov 3, 2006·Critical Care Medicine·Keith R Walley, James A Russell
Apr 10, 2007·Lancet·Roland E SchmiederBernhard M W Schmidt
Sep 19, 2007·The Journal of Experimental Medicine·Tomasz J GuzikDavid G Harrison
Dec 26, 2007·Critical Care Medicine·R Phillip DellingerUNKNOWN World Federation of Societies of Intensive and Critical Care Medicine
Feb 29, 2008·The New England Journal of Medicine·James A RussellUNKNOWN VASST Investigators
Apr 2, 2008·The New England Journal of Medicine·UNKNOWN ONTARGET InvestigatorsCraig Anderson
May 23, 2008·American Journal of Physiology. Renal Physiology·Steven D CrowleyThomas M Coffman
Aug 6, 2008·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Heleen E Bunker-WiersmaAlbert P Bos
Jan 16, 2009·Pediatrics International : Official Journal of the Japan Pediatric Society·Ozgur CoguluFerda Ozkinay
Mar 3, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Toru KawadaMasaru Sugimachi
Mar 28, 2009·Critical Care Medicine·Hector R WongUNKNOWN Genomics of Pediatric SIRS/Septic Shock Investigators
Mar 31, 2009·Journal of Hypertension·Cho-Kai WuFu-Tien Chiang
Apr 17, 2009·The New England Journal of Medicine·John Hardy, Andrew Singleton
May 12, 2009·Nature Genetics·Christopher Newton-ChehPatricia B Munroe
Dec 2, 2009·Critical Care : the Official Journal of the Critical Care Forum·Li WanClive N May
Feb 24, 2010·Critical Care : the Official Journal of the Critical Care Forum·Kevin C DoerschugAlix Ashare

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Aug 5, 2014·American Journal of Respiratory and Critical Care Medicine·Nuala J MeyerMuredach P Reilly
Dec 6, 2011·Respiratory Physiology & Neurobiology·Jia DengHilary Ma
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Oct 4, 2016·Intensive Care Medicine·Anders PernerTimothy Walsh
Mar 7, 2018·Critical Care Medicine·James A TumlinUNKNOWN Angiotensin II for the Treatment of High-Output Shock 3 (ATHOS-3) Investigators
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