Association of angiotensin II type 1 receptor gene polymorphism with carotid atherosclerosis

Clinical Chemistry and Laboratory Medicine : CCLM
Shiming Zhu, Qing-He Meng

Abstract

Polymorphisms of the angiotensin II type 1 receptor (AGTR1) gene are associated with essential hypertension and cardiovascular disease, but the correlation between AGTR1 A1166C polymorphism and carotid intima-media thickness (IMT) remains unclear. We sought to demonstrate correlation between AGTR1 gene polymorphism and carotid atherosclerosis in a Chinese population. A total of 150 patients diagnosed with essential hypertension were included in this study. The AGTR1 A1166C polymorphism was detected by restriction analysis of the polymerase chain reaction product with Ddel digestion. Carotid IMT was measured by B-mode ultrasonography. The AC genotype frequency and the C1166 allele frequency of the AGTR1 gene in essential hypertensive patients were significantly higher than in controls (22.00% vs. 6.00% for AC, p < 0.01; 18.67% vs. 8.00% for the C allele, p < 0.05). Hypertensive subjects with the AC genotype had increased carotid artery IMT and IMT/D (common carotid artery diameter) ratio compared with the AA genotype (IMT 1.14 +/- 0.39 vs. 0.88 +/- 0.16, p < 0.05; IMT/D 14.08 +/- 2.88 vs. 10.51 +/- 1.94, p < 0.01). These results suggest that the AGTR1 A1166C polymorphism is associated with essential hypertension and carotid athe...Continue Reading

References

Feb 18, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Paula Jerrard-DunneMatthias Sitzer
Jul 17, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Teri A ManolioAlexander F Wilson

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Citations

Apr 29, 2010·Current Atherosclerosis Reports·Alan DaughertyLisa A Cassis
Jul 10, 2007·Clinical Chemistry and Laboratory Medicine : CCLM·Marek KiliszekGrzegorz Opolski
Dec 10, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·V MaherD Mc Inerney

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