PMID: 11345362May 10, 2001Paper

Association of angiotensinogen M235T and A(-6)G gene polymorphisms with coronary heart disease with independence of essential hypertension: the PROCAGENE study. Prospective Cardiac Gene

Journal of the American College of Cardiology
J C Rodríguez-PérezC M Ferrario

Abstract

We examined the relationship between the angiotensinogen (AGT) gene M235T polymorphism, the variant promoter of the AGT gene A(-6)G and the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and coronary heart disease (CHD) in native Gran Canaria Island habitants, who have the highest rates of CHD in Spain. Some studies subject that the ACE (I/D) polymorphism could be associated with CHD, while AGT (M235T) has been related to essential hypertension. We studied 304 subjects with angiographic evidence of coronary artery disease and a clinical diagnosis of myocardial infarction or unstable angina and 315 age- and gender-matched controls. Blood was drawn and DNA extracted. Angiotensin-converting enzyme (I/D) gene polymorphism was analyzed by polymerase chain reaction (PCR) and AGT gene polymorphisms by restriction fragment length polymorphism-PCR and mutagenically-separated PCR. The ACE (I/D) polymorphism showed no association with CHD, whereas the frequency distribution of AGT (M235T) genotypes among patients and controls (235T: 29.1% and 19.0%; M235T: 48.5% and 50.2%; M235: 22.4% and 30.8%, respectively) was statistically different (p = 0.005) and not related to the presence of essential hypertension. ...Continue Reading

References

Oct 2, 1992·Cell·X JeunemaitreJ M Lalouel
Nov 1, 1990·The Journal of Pediatrics·M R Sears
Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Aug 1, 1995·The Journal of Clinical Investigation·M CaulfieldA J Clark
Mar 16, 1995·The New England Journal of Medicine·K LindpaintnerC H Hennekens
Oct 20, 1994·The New England Journal of Medicine·M J Brown, D Clayton
Jun 9, 1994·The New England Journal of Medicine·M CaulfieldA J Clark
Oct 1, 1993·PCR Methods and Applications·V ShanmugamB K Saha
Sep 13, 1996·Science·N Risch, K Merikangas
Sep 18, 1997·The Journal of Clinical Investigation·T MorganK Ward
Oct 10, 1997·Hypertension·C M FerrarioD I Diz

❮ Previous
Next ❯

Citations

Apr 29, 2010·Current Atherosclerosis Reports·Alan DaughertyLisa A Cassis
May 28, 2003·International Journal of Cardiology·Monika GoldbergovaJirí Vacha
Feb 8, 2013·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yun-Chul HongMinseon Park
Jul 27, 2011·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Samantha J LuptonJoanne M Lind
Dec 13, 2002·Clinical Chemistry and Laboratory Medicine : CCLM·Tester F AshavaidSunita R Nair
May 20, 2015·Journal of Biological Research·Amal Al-HazzaniAbdulaziz A Al-Jafari
Dec 14, 2011·Clinical and Experimental Hypertension : CHE·Vamsi U MohanaTirunilai Padma
Feb 5, 2014·Clinical and Experimental Hypertension : CHE·G PadmaT Padma
Aug 3, 2005·International Journal of Cardiology·Messias Antônio AraújoHeyder Diniz Silva
Feb 3, 2005·Free Radical Biology & Medicine·Olivier OrmezzanoJean Philippe Baguet
Nov 30, 2013·International Journal of Hypertension·Amy I LynchDonna K Arnett
Mar 16, 2016·The International Journal of Neuroscience·Francisco Rodríguez-EsparragónJosé Carlos Rodríguez-Pérez
Jul 12, 2016·Clinical and Experimental Hypertension : CHE·Padma GundaPadma Tirunilai
Jun 12, 2003·Clinical and Experimental Hypertension : CHE·Francisco Rodríguez-EsparragónCarlos M Ferrario
Jan 4, 2013·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Diana Zaliaduonyte-PeksieneRemigijus Zaliunas
Apr 26, 2003·Heart Disease·Benjamin M SchaeferPamela Charney
Feb 24, 2018·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Irma Isordia-SalasAbraham Majluf-Cruz
Mar 13, 2010·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Georgia RagiaVangelis G Manolopoulos
Jul 29, 2010·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Sounira MehriMohamed Hammami
Jun 14, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Amar Akhtar SethiAnne Tybjaerg-Hansen
Feb 1, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Francisco Rodríguez-EsparragónCarlos M Ferrario
Jun 4, 2008·Current Opinion in Cardiology·Jasper J BrugtsMaarten L Simoons
Oct 5, 2006·Current Opinion in Anaesthesiology·Frank Stüber, Andreas Hoeft
Feb 28, 2008·Journal of Hypertension·Jeroen B van der NetEric Jg Sijbrands
Nov 1, 2017·World Journal of Gastroenterology : WJG·Diego MarquesVivian Nogueira Silbiger
Jul 14, 2012·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Xingsheng LiZhigang Wang
Jan 24, 2014·Journal of the Renin-angiotensin-aldosterone System : JRAAS·G PadmaT Padma
Jul 27, 2010·Clinical Biochemistry·Asad Vaisi-RayganiTayebeh Pourmotabbed

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.