Association of Anti-Porphyromonas gingivalis Antibody Titers With Nonsmoking Status in Early Rheumatoid Arthritis: Results From the Prospective French Cohort of Patients With Early Rheumatoid Arthritis

Arthritis & Rheumatology
Raphaèle SerorXavier Mariette

Abstract

To investigate the possible link between Porphyromonas gingivalis infection and rheumatoid arthritis (RA), according to antibody profile, genetic and environmental factors, and RA severity. For assessing P gingivalis infection, serum levels of antibodies directed against P gingivalis lipopolysaccharide were measured in 694 patients with early RA who were not exposed to steroids or disease-modifying antirheumatic drugs. Anti-P gingivalis antibody titers were compared between patients with early RA and various control groups, and according to various patient characteristics. Anti-P gingivalis antibody titers did not significantly differ between patients with RA and controls and did not significantly differ with anti-citrullinated protein antibody (ACPA), rheumatoid factor (RF), or HLA shared epitope status. Anti-P gingivalis antibody titers were significantly higher among patients who had never smoked compared to patients who had ever smoked (P = 0.0049). Among nonsmokers, high anti-P gingivalis antibody levels were associated with a higher prevalence of erosive change (47.5% versus 33.3% with modified Sharp/van der Heijde score erosion subscale ≥1; P = 0.0135). In this large early RA cohort, we did not detect any association of ...Continue Reading

References

Feb 1, 1980·Arthritis and Rheumatism·J F FriesH R Holman
Jul 17, 2001·Journal of Periodontology·F B MercadoP M Bartold
Jun 7, 2008·Journal of Periodontology·N PischonJ Detert
May 12, 2012·Arthritis and Rheumatism·Jose U ScherSteven B Abramson
Sep 4, 2012·Nature Reviews. Microbiology·George HajishengallisMichael A Curtis
Mar 26, 2013·Journal of Dental Research·S KaurP M Bartold
May 2, 2014·Arthritis & Rheumatology·Ted R MikulsJames R O'Dell

❮ Previous
Next ❯

Citations

Jan 16, 2016·The Journal of Allergy and Clinical Immunology·Ted R MikulsGeoffrey M Thiele
Mar 13, 2016·Autoimmunity Reviews·P ConigliaroR Perricone
Sep 9, 2015·Mediators of Inflammation·Vilana Maria Adriano AraújoVilma Lima
Jul 6, 2016·Clinical Reviews in Allergy & Immunology·Steven R Binder, Christine M Litwin
Aug 25, 2017·Nature Reviews. Rheumatology·Jan PotempaJoanna Koziel
Jul 4, 2019·Current Opinion in Rheumatology·Carlo PerriconeFabrizio Conti
Apr 11, 2020·Journal of Clinical Medicine·Natalia Mena-VázquezAntonio Fernández-Nebro
May 11, 2018·Clinical and Experimental Dental Research·José-Iván Martínez-RiveraJosé-Luis Montiel-Hernández
Feb 15, 2020·Arthritis Research & Therapy·Jerián González-FeblesFederico Díaz-González
Mar 31, 2016·Current Opinion in Rheumatology·Kulveer Mankia, Paul Emery
May 10, 2020·Periodontology 2000·Peter Mark Bartold, Isabel Lopez-Oliva
Oct 17, 2017·Frontiers in Microbiology·Lazaros I SakkasDimitrios P Bogdanos
May 28, 2019·Journal of Clinical Medicine·Mélanie Rinaudo-GaujousHubert Marotte
Aug 12, 2021·Acta Odontologica Scandinavica·Catalina Arévalo-CaroEdgar Garavito-Rodríguez
Aug 20, 2021·Odontology·Steeve BregaintAnne Jolivet-Gougeon
Sep 1, 2021·Periodontology 2000·Jerián González-Febles, Mariano Sanz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.