Association of Antibiotic Utilization and Neurodevelopmental Outcomes among Extremely Low Gestational Age Neonates without Proven Sepsis or Necrotizing Enterocolitis

American Journal of Perinatology
Joseph Y TingCanadian Neonatal Network and Canadian Neonatal Follow-Up Network

Abstract

The objective is to evaluate the association between antibiotic utilization and neurodevelopmental outcomes at 18 to 21 months' corrected age among extremely low gestational age neonates without culture-proven sepsis or necrotizing enterocolitis (NEC). We conducted a retrospective cohort study of infants born between April 2009 and September 2011 at <29 weeks' gestation and admitted to the neonatal intensive care units contributing data to the Canadian Neonatal Network. Multivariable analysis was performed to examine the primary composite outcome of death or significant neurodevelopmental impairment (sNDI) in infants with various antibiotic utilization rates (AURs). There were 1,373 infants who fulfilled our inclusion criteria. Compared with infants in the lowest AUR quartile (Q1), those in the highest quartile (Q4) had higher odds of death or sNDI (adjusted odds ratio [AOR] = 7.44; 95% confidence interval [CI]: 4.55, 12.2) and death (AOR = 39.3; 95% CI: 16.1, 95.9). Our results indicate an association between high AUR and a composite outcome of death or adverse neurodevelopmental outcomes at 18 to 21 months' corrected age.

Citations

Nov 15, 2018·Archives of Disease in Childhood. Fetal and Neonatal Edition·Sagori MukhopadhyayKaren M Puopolo
Feb 20, 2020·Nutrients·Fiammetta PiersigilliOlivier Danhaive
Aug 15, 2020·Journal of Perinatology : Official Journal of the California Perinatal Association·Samuel J GarberSagori Mukhopadhyay
Jan 31, 2021·Maternal Health, Neonatology and Perinatology·Alaina K PylePablo J Sánchez
Nov 23, 2020·Seminars in Perinatology·Michael W Kuzniewicz, Karen M Puopolo
Jun 5, 2021·Journal of Paediatrics and Child Health·Sujit Gorantiwar, Koert de Waal
Aug 31, 2021·The Journal of Pediatrics·Siyuan JiangUNKNOWN REIN-EPIQ Study Group
Sep 18, 2021·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Joseph Y TingUNKNOWN Canadian Neonatal Network (CNN) Investigators a
Mar 2, 2019·Pediatrics·Joseph Y TingUNKNOWN Canadian Neonatal Network Investigators
May 25, 2020·The Journal of Pediatrics·Sagori MukhopadhyayUNKNOWN Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network

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