Association of anticonvulsant hypersensitivity syndrome with Herpesvirus 6, 7

Epilepsy Research
Tuğba OskayOzcan I Ertürk

Abstract

Anticonvulsant hypersensitivity syndrome (AHS) is one of the most severe forms of drug eruption with potentially lethal, and multiorgan involvement. Recently, it has been suggested that Human Herpesvirus (HHV) infection has been involved in this syndrome, although the pathogenesis of this syndrome remains still unclear. The objective of this study was to determine the clinical characteristics of AHS and the possible role of viral infection as a co-factor. We prospectively analyzed clinical, laboratory and virological findings for 23 cases of AHS. A viral study including viral serology and a polymerase chain reaction (PCR) was performed. The most common anticonvulsant was carbamazepine (12) followed by phenytoin (6), phenobarbital (4) and gabapentin (1). All patients met fulfill the clinical criteria of AHS. Even though internal organ involvement such as liver (52%), kidney (34%), and lung (13%) has been observed, involvement of heart, lung, thyroid, muscle, pancreas, spleen, and brain was less frequent. We also noted two patients who died due to multiorgan failure. No association with viral infection including HSV, VZV, HHV-8, CMV, EBV, measles, rubella and parvovirus B19 was detected in the current series. Increased serum anti...Continue Reading

References

Dec 1, 1988·The Journal of Clinical Investigation·N H Shear, S P Spielberg
Nov 10, 1994·The New England Journal of Medicine·J C Roujeau, R S Stern
Oct 8, 1998·Archives of Dermatology·L Le CleachO Chosidow
Apr 13, 1999·Cleveland Clinic Journal of Medicine·H M Hamer, H H Morris
Mar 24, 2000·The British Journal of Dermatology·J R Sullivan, N H Shear
Mar 20, 2001·JAMA : the Journal of the American Medical Association·N SekineK Kikuchi
Jun 26, 2001·The British Journal of Dermatology·M AiharaZ Ikezawa
Feb 15, 2002·Archives of Dermatology·Mikiko Tohyama, Koji Hashimoto
Jul 12, 2002·Annals of Neurology·Yasuhiro FujinoTatsuo Yamada
Nov 16, 2002·The Journal of Dermatology·Yayoi NagaiOsamu Ishikawa
May 29, 2003·Dermatology : International Journal for Clinical and Investigative Dermatology·S Tas, T Simonart
Jul 2, 2003·Journal of the European Academy of Dermatology and Venereology : JEADV·M BabaH R Memişoglu
Jan 8, 2004·Journal of Clinical Psychopharmacology·Tomomi OgiharaKazuhiko Matsumoto
Feb 18, 2004·Archives of Dermatology·Gavin A E Wong, Neil H Shear
Mar 27, 2004·Southern Medical Journal·Jenester MostellaChristopher K Finch
Dec 21, 2004·Journal of Child Neurology·Wing-Cheong LeeVirginia Wong
Apr 23, 2005·Acta Dermato-venereologica·Yoko Kano, Tetsuo Shiohara
Aug 10, 2005·Dermatology : International Journal for Clinical and Investigative Dermatology·Hiroyuki HaraHiroyuki Suzuki

❮ Previous
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Citations

Jun 6, 2012·International Journal of Hepatology·Joshua C PritchettManuela G Neuman
Apr 6, 2013·Pediatric Emergency Care·Ninela IrgaElzbieta Adamkiewicz-Drozynska
Jul 17, 2012·Expert Opinion on Drug Safety·Sandra R KnowlesNeil H Shear
Dec 24, 2010·Thérapie·Amel ChaabaneNaceur A Boughattas
Dec 12, 2007·Seminars in Cutaneous Medicine and Surgery·Jonathan Cotliar
Sep 28, 2007·Pharmacotherapy·KarenBeth H BohanNatalie M Wilson
May 19, 2007·Pediatric Neurology·Akihisa OkumuraKazuyoshi Watanabe
Feb 25, 2009·Journal of Dermatological Science·Takahiro WatanabeKunihiko Tamaki
Jul 27, 2015·Immunology and Allergy Clinics of North America·Casey Curtis, Princess U Ogbogu
Apr 23, 2013·Journal of the American Academy of Dermatology·Zain HusainRobert A Schwartz
Mar 25, 2011·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Pavels GordinsKonrad S Staines
Mar 2, 2010·Internal Medicine·Yoshiro FujitaKayoko Matsunaga
May 6, 2015·Asia Pacific Allergy·Dinh Van NguyenSheryl van Nunen
Jan 11, 2018·Expert Review of Neurotherapeutics·Ettore Beghi, Josemir W Sander
Feb 24, 2021·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Sophia Tsabouri, Marina Atanaskovic-Markovic

❮ Previous
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