Association of Apathy With Risk of Incident Dementia: A Systematic Review and Meta-analysis

JAMA Psychiatry
Jan Willem van DalenEdo Richard

Abstract

Fear of dementia is pervasive in older people with cognitive concerns. Much research is devoted to finding prognostic markers for dementia risk. Studies suggest apathy in older people may be prodromal to dementia and could be a relevant, easily measurable predictor of increased dementia risk. However, evidence is fragmented and methods vary greatly between studies. To systematically review and quantitatively synthesize the evidence for an association between apathy in dementia-free older individuals and incident dementia. Two reviewers conducted a systematic search of Medline, Embase, and PsychINFO databases. Inclusion criteria were (1) prospective cohort studies, (2) in general populations or memory clinic patients without dementia, (3) with clear definitions of apathy and dementia, and (4) reporting on the association between apathy and incident dementia. PRISMA and MOOSE guidelines were followed. Data were extracted by 1 reviewer and checked by a second. Main outcomes were pooled crude risk ratios, maximally adjusted reported hazard ratios (HR), and odds ratios (OR) using DerSimonian-Laird random effects models. The mean age of the study populations ranged from 69.2 to 81.9 years (median, 71.6 years) and the percentage of wo...Continue Reading

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Apr 18, 2019·International Journal of Geriatric Psychiatry·Valeria ManeraPhilippe Robert
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