Association of APOE-C1 gene cluster polymorphisms with gallstone disease.

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Manjusha DixitBalraj Mittal

Abstract

Genetic polymorphisms in apolipoprotein genes may be associated with alteration in lipid profile and susceptibility to gallstone disease. To find out the association of APOE HhaI and APOC1 HpaI polymorphisms with gallstone disease. HhaI polymorphism of APOE and HpaI polymorphism of APOC1 were analysed in DNA samples of 214 gallstone patients and 322 age- and sex-matched healthy controls. For genotyping DNA samples of all study subjects were amplified using polymerase chain reaction, followed by restriction digestion. All statistical analyses were done using SPSS v11.5 and ARLEQUIN v2.0 softwares. APOC1 HpaI polymorphism was found to be significantly associated with gallstone disease. Frequency of H2H2 was significantly higher (P = 0.017) in patients than in controls and it was imposing very high risk (OR 9.416, 95% CI 1.125-78.786) for gallstone disease. When data were stratified in male and female, H2H2 was associated (P = 0.011) with disease in females only. Analysis at allele level revealed no association. APOE HhaI polymorphism and APOE-C1 haplotypes showed no association with gallstone disease. APOC1 HpaI polymorphism is associated with gallstone disease and shows gender-specific differences. APOE HhaI polymorphism may not...Continue Reading

References

Jul 1, 1991·American Journal of Epidemiology·G C MohrE Barrett-Connor
Sep 1, 1990·Gastroenterology·C ThijsP Brombacher
Dec 1, 1989·Gut·Y Antero KesäniemiT A Miettinen
Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Dec 1, 1987·The Journal of Clinical Investigation·M S WeintraubJ L Breslow
Sep 1, 1984·British Medical Journal·R K ScraggJ R Oliver
Jun 1, 1993·Gastroenterology·T JuvonenY A Kesäniemi
Sep 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P PortincasaG P van Berge-Henegouwen
Dec 1, 1996·Gastroenterology·A BertomeuJ M Ribó
Dec 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C W KoS P Lee
Oct 9, 2001·European Journal of Clinical Investigation·S FischerD Jüngst
Oct 5, 2002·Journal of Lipid Research·Jeffrey S CohnJean Davignon
Jul 23, 2003·The American Journal of Gastroenterology·Kiyoshi HasegawaMasatoshi Makuuchi
Jun 12, 2004·Current Gastroenterology Reports·David Q-H Wang, Nezam H Afdhal
Mar 5, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Despina KatsikaHanns-Ulrich Marschall

❮ Previous
Next ❯

Citations

May 25, 2010·Biochemical and Biophysical Research Communications·Hanns-Ulrich MarschallCurt Einarsson
Mar 10, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Silvana Zanlungo, Attilio Rigotti
Aug 19, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Sachchida Nand PandeyB Mittal
Mar 1, 2008·Journal of Hepatology·Frank Lammert, Juan-Francisco Miquel
Sep 23, 2014·Clinics and Research in Hepatology and Gastroenterology·Satoko Hirobe-JahnEduard F Stange
Apr 15, 2008·Current Opinion in Gastroenterology·Aksana Höblinger, Frank Lammert
Nov 30, 2019·International Journal of Molecular Sciences·Elena V Fuior, Anca V Gafencu
Jul 11, 2020·Indian Journal of Clinical Biochemistry : IJCB·Tripty ChauhanB Mittal

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.