Association of APOE (Hha1) and ACE (I/D) gene polymorphisms with type 2 diabetes mellitus in North West India

Diabetes Research and Clinical Practice
Puneet Pal SinghSarabjit Mastana

Abstract

Familial and epidemiological studies have shown that genetic factors play a role in the development and progression of type 2 diabetes mellitus (T2DM). Asian Indians have shown an increasing prevalence of T2DM. Apolipoprotein E (APOE) and Angiotensin-1 converting enzyme (ACE) I/D polymorphisms have been associated with T2DM. This study examined the association of APOE and ACE genes with T2DM patients of Punjab, India. APOE (HhaI) and ACE (I/D) genotypes analysed by polymerase chain reaction were available from 90 patients and 97 random healthy controls. All loci and populations are in Hardy-Weinberg equilibrium. There is no significant association of APOE vis-à-vis T2DM, however APOE*4 allele frequency is low in diabetics (3.9% and 8.8%). DD genotype and *D allele of ACE are associated with T2DM (OR=1.90, p<0.05, and OR=1.58, p<0.05, respectively). Recessive and multiplicative mode of inheritance for *D allele provided the strongest support for the association. Height, weight and BMI did not reveal any significant association with APO or ACE. DD-33 and ID-23 combinations (ACE-APOE) showed higher odds of 2.01 and 2.14, respectively. ACE but not APOE polymorphism is positively associated with T2DM in Indian population, however, t...Continue Reading

References

Dec 1, 1992·Annals of Medicine·A Ramachandran
Oct 1, 1993·PCR Methods and Applications·V ShanmugamB K Saha
Feb 1, 1997·Diabetologia·A RamachandranM Viswanathan
Apr 8, 1998·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·H KimuraM Arakawa
Sep 17, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·S K HaD S Han
Jul 31, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Masaaki EtoKohei Kaku
Dec 24, 2002·Human Biology·Puneet Pal SinghSarabjit S Mastana
Apr 23, 2003·Diabetes Research and Clinical Practice·D S PowellA Clark
Jan 30, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Evagelos LiberopoulosMoses Elisaf
Jan 11, 2005·Molecular Genetics and Metabolism·Jeffrey W StephensSteve E Humphries
Jun 7, 2005·Expert Opinion on Therapeutic Targets·Sheila A Doggrell
Nov 10, 2006·Annals of Human Biology·P P SinghS S Mastana

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Citations

Feb 28, 2009·BMC Bioinformatics·Yueyi I LiuAtul J Butte
Apr 2, 2008·International Journal of Cardiology·Puneetpal SinghTaranpal Kaur
Jan 15, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Louis A Profenno, Stephen V Faraone
Apr 12, 2008·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Imen ArfaSonia Abdelhak
Apr 7, 2010·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Sangeeta AdakMaitree Bhattacharyya
Mar 17, 2009·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Thouraya BaroudiAmel Benammar-Elgaaied
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity

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