Association of APOE polymorphisms with diabetes and cardiometabolic risk factors and the role of APOE genotypes in response to anti-diabetic therapy: results from the AIDHS/SDS on a South Asian population

Journal of Diabetes and Its Complications
Bishwa SapkotaDharambir K Sanghera

Abstract

Apolipoprotein E (APOE) gene polymorphisms have been examined extensively in multiple global populations particularly due to their crucial role in lipid metabolism and cardiovascular disease. However, the overall contribution of APOE polymorphisms in type 2 diabetes (T2D) and coronary artery disease (CAD) in South Asians is still under-investigated. The objectives of this investigation were: 1) to evaluate the distribution of APOE polymorphisms in a large diabetic case-control sample from South Asia, 2) to examine the impact of APOE polymorphisms on quantitative risk factors of T2D and CAD, and 3) to explore the contribution of APOE genotypes in the response to anti-diabetic therapy. A total of 3564 individuals (1956 T2D cases and 1608 controls) used in this study were part of the Asian Indian Diabetic Heart Study/Sikh Diabetes Study (AIDHS/SDS). We assessed the association of APOE polymorphisms with T2D, CAD and cardiometabolic traits using logistic and linear regression analysis. No significant differences in the distribution of APOE genotypes were observed between T2D and CAD cases and controls. The APOE4 genotype carriers had moderately higher diastolic blood pressure (BP) (p=0.022), and lower HDL-cholesterol (p=0.026) comp...Continue Reading

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Citations

Jul 31, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Masaaki EtoKohei Kaku
Nov 22, 2016·BioMed Research International·Min XuLina Wang
Feb 18, 2021·Genetic Testing and Molecular Biomarkers·Chang GaoGangMing Shu
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Oct 12, 2021·Expert Opinion on Drug Metabolism & Toxicology·Natalie R NeumannVasilis Vasiliou

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