PMID: 15222689Jun 30, 2004Paper

Association of apolipoprotein E and myeloperoxidase genotypes to clinical course of familial and sporadic multiple sclerosis

Multiple Sclerosis : Clinical and Laboratory Research
B Zakrzewska-PniewskaH Kwiecinski

Abstract

The importance of apolipoprotein E (ApoE) and myeloperoxidase (MPO) genotypes in the clinical characteristics of multiple sclerosis (MS) has been recently emphasized. In a large group of Polish patients we have tested the hypothesis that polymorphism in ApoE and MPO genes may influence the course of the disease. Genotypes were determined in 117 MS patients (74 females and 43 males; 99 sporadic and 18 familial cases) with mean EDSS of 3.6, mean age of 44. 1 years, mean duration of the disease 12.8 years and mean onset of MS at 31.2 years, and in 100 healthy controls. The relationship between ApoE and MPO genes' polymorphism and the MS activity as well as the defect of remyelination (diffuse demyelination) and brain atrophy on MRI were analysed. The ApoE epsilon4 allele was not related to the disease course or the ApoE epsilon2 to the intensity of demyelination on MRI. The genotype MPO G/G was found in all familial MS and in 57% (56/99) of sporadic cases. This genotype was also related to more pronounced brain atrophy on MRI. The MPO G/G subpopulation was characterized by a significantly higher proportion of patients with secondary progressive MS (P < 0.05) and by a higher value of EDSS. According to our results the MPO G allele ...Continue Reading

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Citations

Sep 20, 2005·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Chikako KiyoharaYoichi Nakanishi
Oct 1, 2005·Multiple Sclerosis : Clinical and Laboratory Research·M PinholtM Christiansen
Apr 6, 2006·Journal of Magnetic Resonance Imaging : JMRI·Valerie M AndersonDavid H Miller
Jul 23, 2009·Antioxidants & Redox Signaling·Betty S van der VeenPeter Heeringa
Jul 7, 2007·Multiple Sclerosis : Clinical and Laboratory Research·F LundmarkJ Hillert
Jun 27, 2006·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M PinholtM Christiansen
Aug 29, 2009·Molecular Diagnosis & Therapy·Violaine K Harris, Saud A Sadiq
Feb 14, 2007·Multiple Sclerosis : Clinical and Laboratory Research·B A ParmenterL M Harlan
Mar 12, 2008·Antioxidants & Redox Signaling·Michael J DaviesMartin D Rees
Sep 18, 2007·Expert Review of Neurotherapeutics·Masaaki NiinoHidenao Sasaki
Mar 1, 2006·Journal of Negative Results in Biomedicine·I MannaA Quattrone
Nov 26, 2010·Journal of Molecular Neuroscience : MN·Mir SajadHaider A Khan
Sep 9, 2006·Cellular Signalling·Yann Wan YapNam Sang Cheung

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