Association of apolipoprotein E polymorphism with lipoprotein glomerulopathy. Report of 2 cases with a new genotype and comparison of the relative frequencies of apolipoprotein E isoforms in lipoprotein glomerulopathy and in the general population

Nephron
A H YangJ T Kao

Abstract

Two cases of lipoprotein glomerulopathy with a new apolipoprotein E (Apo E) genotype, epsilon3/epsilon4, were diagnosed recently. These 2 cases, together with other cases documented in English literature made a total of 6 common isoforms of Apo E encountered in lipoprotein glomerulopathy. Although the calculated allele frequency of epsilon2 is relatively high in cases with lipoprotein glomerulopathy as compared with that in the general population (39.3 vs. 6.4-11.4%), the gradual emergence of Apo E isoforms other than E2/E3 in lipoprotein glomerulopathy implicates that the genetic susceptibility of certain Apo E isoforms may not be a crucial factor. An alteration in the local environment of glomerular capillaries may be more important in the pathogenesis of lipoprotein glomerulopathy.

Citations

Feb 22, 2001·Journal of the American Society of Nephrology : JASN·Michael M HoffmannWinfried März
Dec 25, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Norio IeiriYoshio Taguma
Sep 5, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Chao-Fu ChangWu-Chang Yang
Jan 25, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Takao SaitoShinichi Oikawa
Feb 24, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ramin SamAshok K Singh

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