Association of arterial blood pressure and vasopressor load with septic shock mortality: a post hoc analysis of a multicenter trial.

Critical Care : the Official Journal of the Critical Care Forum
Martin W DünserJukka Takala

Abstract

It is unclear to which level mean arterial blood pressure (MAP) should be increased during septic shock in order to improve outcome. In this study we investigated the association between MAP values of 70 mmHg or higher, vasopressor load, 28-day mortality and disease-related events in septic shock. This is a post hoc analysis of data of the control group of a multicenter trial and includes 290 septic shock patients in whom a mean MAP > or = 70 mmHg could be maintained during shock. Demographic and clinical data, MAP, vasopressor requirements during the shock period, disease-related events and 28-day mortality were documented. Logistic regression models adjusted for the geographic region of the study center, age, presence of chronic arterial hypertension, simplified acute physiology score (SAPS) II and the mean vasopressor load during the shock period was calculated to investigate the association between MAP or MAP quartiles > or = 70 mmHg and mortality or the frequency and occurrence of disease-related events. There was no association between MAP or MAP quartiles and mortality or the occurrence of disease-related events. These associations were not influenced by age or pre-existent arterial hypertension (all P > 0.05). The mean ...Continue Reading

References

Jun 1, 1992·Critical Care Medicine·R C BoneW J Sibbald
Jun 16, 1994·The New England Journal of Medicine·M A HayesD Watson
Dec 22, 1993·JAMA : the Journal of the American Medical Association·J R Le GallF Saulnier
Mar 1, 1997·Critical Care Medicine·A Meier-HellmannL Hannemann
Aug 31, 2000·Critical Care Medicine·D LeDouxE C Rackow
Jan 17, 2002·The New England Journal of Medicine·E RiversUNKNOWN Early Goal-Directed Therapy Collaborative Group
Aug 18, 2004·Critical Care : the Official Journal of the Critical Care Forum·Rinaldo BellomoUNKNOWN Acute Dialysis Quality Initiative workgroup
Oct 30, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Tero J MartikainenEsko Ruokonen
Nov 16, 2004·Critical Care Medicine·Richard J BealeJoseph E Parrillo
Jun 24, 2005·Intensive Care Medicine·Marjut VarpulaVille Pettilä
Jul 18, 2006·Methods and Findings in Experimental and Clinical Pharmacology·S KatsaragakisI Bramis
Nov 14, 2006·Journal of Thrombosis and Haemostasis : JTH·C H TohUNKNOWN SSC on Disseminated Intravascular Coagulation of the ISTH
Dec 26, 2007·Critical Care Medicine·R Phillip DellingerUNKNOWN World Federation of Societies of Intensive and Critical Care Medicine
Feb 29, 2008·The New England Journal of Medicine·James A RussellUNKNOWN VASST Investigators
Dec 31, 2008·Critical Care Medicine·Pedro R PóvoaUNKNOWN Portuguese Community-Acquired Sepsis Study Group
Feb 4, 2009·Intensive Care Medicine·Martin W DünserStephan M Jakob
Aug 26, 2009·Journal of Intensive Care Medicine·Martin W Dünser, Walter R Hasibeder

❮ Previous
Next ❯

Citations

Feb 22, 2012·Intensive Care Medicine·Martin W DünserUNKNOWN Global Intensive Care Working Group of European Society of Intensive Care Medicine
Apr 25, 2012·Intensive Care Medicine·Christian A SchmittingerMartin W Dünser
Mar 5, 2011·Critical Care : the Official Journal of the Critical Care Forum·Jens AltrichterSteffen R Mitzner
Jun 8, 2011·Critical Care : the Official Journal of the Critical Care Forum·Julie BadinDominique Perrotin
Jun 17, 2011·Critical Care : the Official Journal of the Critical Care Forum·Jukka TakalaStephan M Jakob
Sep 6, 2011·Critical Care : the Official Journal of the Critical Care Forum·Mervyn Singer, David Brealey
Sep 15, 2011·Critical Care : the Official Journal of the Critical Care Forum·Sarah E SiegelaarJ Hans DeVries
Feb 1, 2013·Critical Care : the Official Journal of the Critical Care Forum·Thiago Domingos CorrêaStephan Mathias Jakob
Mar 29, 2013·Critical Care : the Official Journal of the Critical Care Forum·François BelonclePierre Asfar
Oct 10, 2013·Critical Care : the Official Journal of the Critical Care Forum·Martin W DünserJan Bakker
Oct 9, 2013·Critical Care : the Official Journal of the Critical Care Forum·Ilse Gradwohl-Matis, Martin W Dünser
Jan 23, 2010·Critical Care : the Official Journal of the Critical Care Forum·Alan E JonesR Phillip Dellinger
Dec 18, 2013·Critical Care : the Official Journal of the Critical Care Forum·Meri PoukkanenUNKNOWN FINNAKI Study Group
Feb 2, 2013·World Journal of Surgery·Marc KastrupClaudia Spies
Jan 5, 2011·Critical Care Medicine·Jukka Takala
Feb 14, 2016·Intensive Care Medicine·Davide Tommaso Andreis, Mervyn Singer
Aug 23, 2012·Chest·Samuel M BrownAlan H Morris
Mar 13, 2016·Critical Care : the Official Journal of the Critical Care Forum·Aletta P I HouwinkPeter H J van der Voort
Mar 6, 2012·Acta Anaesthesiologica Scandinavica·A PernerL B Holst
Feb 24, 2011·Acta Anaesthesiologica Scandinavica·S CarlsenUNKNOWN East Danish Septic Shock Cohort Investigators
Jan 10, 2013·Acta Anaesthesiologica Scandinavica·E WilkmanM Varpula
Aug 14, 2015·British Journal of Anaesthesia·J P R MooreJ Fraser
Sep 2, 2015·Brazilian Journal of Anesthesiology·Leonardo Lima RochaEliézer Silva
Aug 25, 2015·Revista brasileira de anestesiologia·Leonardo Lima RochaEliézer Silva
Feb 4, 2014·Seminars in Immunology·Mark K LukewichAlan E Lomax
Apr 19, 2015·Critical Care : the Official Journal of the Critical Care Forum·Thiago D CorrêaStephan M Jakob
May 24, 2014·BMJ Case Reports·Mohamed Saleh
Apr 19, 2015·Critical Care : the Official Journal of the Critical Care Forum·Marc LeoneClaude Martin
Jun 19, 2015·Critical Care : the Official Journal of the Critical Care Forum·Thiago Domingos CorrêaJukka Takala
Feb 24, 2015·Intensive Care Medicine·Anthony C Gordon
Jul 12, 2016·American Journal of Respiratory and Critical Care Medicine·Roeland F StolkMatthijs Kox
Nov 12, 2015·Medizinische Klinik, Intensivmedizin und Notfallmedizin·J C LewejohannT Keck
Oct 6, 2016·The New England Journal of Medicine·Anthony C GordonDeborah Ashby
Nov 1, 2016·Intensive Care Medicine·Anders Perner, Mervyn Singer

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Methods Mentioned

BETA
pregnancy test
sedation

Software Mentioned

SPSS

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