Association of Bartonella spp bacteremia with Chagas cardiomyopathy, endocarditis and arrhythmias in patients from South America.

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
F G CorrêaH S Selistre-de-Araujo

Abstract

Infection with Bartonella spp may cause cardiac arrhythmias, myocarditis and endocarditis in humans. The aim of the present study was to evaluate a possible association between Bartonella spp bacteremia and endocarditis, arrhythmia and Chagas cardiomyopathy in patients from Brazil and Argentina. We screened for the presence of bacterial 16S rRNA in human blood by PCR using oligonucleotides to amplify a 185-bp bacterial DNA fragment. Blood samples were taken from four groups of subjects in Brazil and Argentina: i) control patients without clinical disease, ii) patients with negative blood-culture endocarditis, iii) patients with arrhythmias, and iv) patients with chronic Chagas cardiomyopathy. PCR products were analyzed on 1.5% agarose gel to visualize the 185-bp fragment and then sequenced to confirm the identity of DNA. Sixty of 148 patients (40.5%) with cardiac disease and 1 of 56 subjects (1.8%) from the control group presented positive PCR amplification for Bartonella spp, suggesting a positive association of the bacteria with these diseases. Separate analysis of the four groups showed that the risk of a Brazilian patient with endocarditis being infected with Bartonella was 22 times higher than in the controls. In arrhythmi...Continue Reading

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Citations

Jul 22, 2015·Emerging Infectious Diseases·Rinaldo Focaccia SicilianoTania Mara Varejao Strabelli
Nov 20, 2013·Veterinary Microbiology·Gabriel L CicuttinHoracio Gil
Mar 22, 2016·PLoS Neglected Tropical Diseases·Pedro Paulo Vissotto de Paiva DinizDiana Gerardi Scorpio
Nov 30, 2019·Anais Brasileiros De Dermatologia·Karina de Almeida LinsPaulo Eduardo Neves Ferreira Velho

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Methods Mentioned

BETA
PCR
blood collection
biopsies

Software Mentioned

BLAST

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