Association of Baseline Inflammation With Effectiveness of Nutritional Support Among Patients With Disease-Related Malnutrition: A Secondary Analysis of a Randomized Clinical Trial

JAMA Network Open
Meret MerkerPhilipp Schuetz

Abstract

Inflammation is a key driver of malnutrition during illness and is often accompanied by metabolic effects, including insulin resistance and reduction of appetite. However, it still remains unclear if inflammation influences the response to nutritional support among patients with disease-related malnutrition. To examine whether patients' baseline inflammatory status is associated with the effect of nutritional support on 30-day mortality. This is a secondary analysis of the Effect of Early Nutritional Support on Frailty, Functional Outcomes, and Recovery of Malnourished Medical Inpatients Trial (EFFORT), a randomized clinical trial conducted in 8 Swiss hospitals from April 2014 to February 2018. A total of 1950 participants who had C-reactive protein measurements at the time of admission were included in this secondary analysis. Data analysis was conducted between June and July 2019. Hospitalized patients at risk for malnutrition were randomly assigned to receive protocol-guided individualized nutritional support to reach protein and energy goals (intervention group) or standard hospital food (control group). The primary end point was 30-day mortality. Based on C-reactive protein levels at admission, patients were stratified int...Continue Reading

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Citations

Oct 31, 2020·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·David C EvansUNKNOWN ASPEN Malnutrition Committee
Feb 14, 2021·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·David C EvansAinsley Malone
Sep 14, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Nina Kaegi-BraunPhilipp Schuetz
Mar 21, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Andriana EfthymiouUNKNOWN EFFORT study group
Oct 22, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Annic BaumgartnerPhilipp Schuetz
Apr 6, 2021·JPEN. Journal of Parenteral and Enteral Nutrition·Julia Carvalho VenturaUNKNOWN PICU-ScREEN Study Group
May 3, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Annika BargetziPhilipp Schuetz
May 23, 2021·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L BargetziP Schuetz
Jun 27, 2021·International Urology and Nephrology·Liling ChenShiqun Chen
Aug 15, 2020·Journal of the American College of Cardiology·Sergio Raposeiras RoubínAndrés Íñiguez Romo
Aug 25, 2021·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L BargetziP Schuetz
Aug 30, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Tristan StrujaPhilipp Schuetz

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Methods Mentioned

BETA
gastric bypass

Software Mentioned

EFFORT
Stata

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