PMID: 8591709Sep 1, 1995Paper

Association of below-knee atherosclerosis to medial arterial calcification in diabetes mellitus

Diabetes Research and Clinical Practice
E ChantelauR Jungblut

Abstract

In diabetes mellitus, peripheral arterial occlusive disease (PAOD) more often affects the lower rather than the upper leg. It is hypothesized that peripheral medial arterial calcification (MAC) may be related to this phenomenon. In 42 diabetic patients subjected to arteriography for PAOD, forefoot roentgenogrammes were also obtained for assessment of MAC, e.g. of the metatarsal arteries. The distribution of PAOD (number of partial and total arterial stenoses per leg) was assessed according to the coexistence of MAC. A total of 242 partial and complete stenoses was found in 35 MAC-positive legs and 28 MAC-negative legs. MAC-positive legs displayed 4 (3-6) stenoses per leg (median with 95% confidence interval), vs. 3 (2-5) stenoses per MAC-negative leg. MAC-positive legs had more than twice as many stenoses located in the lower (2.6 (2.3-2.8) stenoses below knee) as compared to the upper leg (1.3 (1.0-1.7) stenoses above knee; P < 0.05), whereas stenoses were equally distributed above and below the knee in MAC-negative legs. The prevalence of stenoses in the truncus tibiofibularis and in the foot arteries (e.g. arteria dorsalis pedis) was unaffected by MAC-status. In conclusion, the predominance of PAOD in the lower leg of diabet...Continue Reading

Citations

Mar 30, 2013·Current Cardiovascular Risk Reports·Carlos Iribarren, Sabee Molloi
Sep 4, 2015·Diabetes/metabolism Research and Reviews·R J HinchliffeUNKNOWN International Working Group on the Diabetic Foot
Apr 26, 2011·Annals of Vascular Surgery·Dimitri AerdenPierre Van den Brande
Sep 8, 2004·Expert Review of Cardiovascular Therapy·Pavel CrystalEugene Crystal
Mar 5, 2008·Foot & Ankle International·Christopher David SmithMelwyn Pereira
Oct 28, 2019·Cardiovascular Endocrinology & Metabolism·Michael Edmonds
Jan 21, 2020·Diabetes/metabolism Research and Reviews·Robert J HinchliffeUNKNOWN International Working Group on the Diabetic Foot (IWGDF)
Feb 7, 2007·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·Robert G FrykbergUNKNOWN American College of Foot and Ankle Surgeons

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