Association of beta-fibrinogen gene -148C/T and -455G/A polymorphisms and coronary artery disease in Chinese population: a meta analysis

Science in China. Series C, Life Sciences
Xiao-chao ChenWei-qing Chen

Abstract

The purpose of our study was to evaluate the correlation between the beta-fibrinogen gene -148C/T and -455G/A polymorphisms and susceptibility to coronary artery disease in the Chinese population using a meta-analytic approach. Eligible studies about this correlation were identified by searching the PubMed, EMBASE, and CNKI databases. Of the 13 identified, 7 (with 1488 cases and 1234 controls) involved the -148C/T polymorphism and 9 (with 1023 cases and 1081 controls) involved the -455G/A polymorphism. No publication bias was detectable and heterogeneity testing found significant differences between the ORs for both groups of studies. The combined OR for the 7 studies on susceptibility to coronary artery disease in -148T allele carriers compared to the -148C/C wild-type homozygotes was 1.31 (95%CI: 0.94-1.84, P = 0.11). The combined OR for the 9 studies on susceptibility to coronary artery disease in -455A allele carriers compared to the -455G/G wild-type homozygotes was 1.75 (95%CI: 1.24-2.46, P = 0.001). Our results suggest the absence of an association between the beta-fibrinogen gene -148C/T polymorphism and susceptibility to coronary artery disease and the possibility that -455G/A polymorphism (in particular, allele A) inc...Continue Reading

References

Aug 23, 1984·The New England Journal of Medicine·L WilhelmsenG Tibblin
Jun 15, 1993·Annals of Internal Medicine·E Ernst, K L Resch
Jun 26, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Eleanor M ScottPeter J Grant
Mar 12, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·José Manuel SoriaJordi Fontcuberta

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Citations

Aug 25, 2016·Revista Española De Cardiología·Nikolaos PapageorgiouDimitris Tousoulis
Feb 20, 2015·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Wael AlkhiarySolafa El-Sharawy
Mar 15, 2018·Journal of Medical Ultrasonics·Vacis TatarunasVaiva Lesauskaite

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