Association of beta2-adrenoreceptor genotypes with bronchodilatory effect of tiotropium in COPD

Respirology : Official Journal of the Asian Pacific Society of Respirology
Nobuaki UmedaShigeo Fujimoto

Abstract

Recently, there has been interest in interactions of beta(2) adrenergic receptors (beta(2)-AR) and muscarinic acetylcholine receptors (mAChR), which share intracellular signal transduction systems. The aim of the present study was to investigate whether bronchodilator response to tiotropium is influenced by beta(2)-AR genotype in patients with COPD who show poor responsiveness to inhaled beta(2)-agonists. After a 4-week run-in period, patients with COPD were treated with inhaled tiotropium bromide (18 microg once daily) for 8 weeks. Spirometric measurements and reversibility testing with inhaled beta(2)-AR agonists were performed and health-related quality of life was assessed using the St George's respiratory questionnaire (SGRQ) before and after treatment. Genomic DNA was prepared from peripheral blood and individual genotypes at amino acid 16 of the beta(2)-AR were examined. Forty-four patients with COPD completed the study. COPD patients with the Arg/Arg genotype (n = 22) had a significant increase in FEV(1) during treatment compared with those without the Arg/Arg genotype (n = 22) (FEV(1), P = 0.009; FEV(1)%, P = 0.006). While all component and total scores on the SGRQ improved significantly in both genetic groups, changes...Continue Reading

References

Jun 1, 1992·The American Review of Respiratory Disease·P W JonesP Littlejohns
Aug 16, 1984·The New England Journal of Medicine·N J Gross, M S Skorodin
Jan 1, 1993·Life Sciences·P J Barnes
Jan 1, 1997·Life Sciences·S R NahorskiG B Willars
Jan 1, 1997·Life Sciences·J ZaagsmaH Meurs
Sep 10, 1998·American Journal of Respiratory and Critical Care Medicine·T D WeirP D Paré
Nov 11, 1999·American Journal of Respiratory and Critical Care Medicine·P J Barnes
Feb 15, 2000·American Journal of Respiratory and Critical Care Medicine·M UlbrechtE H Weiss
Feb 17, 2001·American Journal of Respiratory and Critical Care Medicine·A J SandfordP D Paré
Aug 3, 2002·American Journal of Respiratory and Critical Care Medicine·Jian-Qing HeAndrew J Sandford
Oct 27, 2004·Lancet·Elliot IsraelUNKNOWN National Heart, Lung, and Blood Institute's Asthma Clinical Research Network
Dec 15, 2004·Chest·Ahmed E HegabKiyohisa Sekizawa
Feb 5, 2005·Respirology : Official Journal of the Asian Pacific Society of Respirology·UNKNOWN Asia Pacific COPD Roundtable Group
Mar 16, 2005·Biochemical and Biophysical Research Communications·Ahmed E HegabKiyohisa Sekizawa
May 10, 2005·American Journal of Respiratory and Critical Care Medicine·Cleo C van DiemenH Marike Boezen
Nov 4, 2005·Proceedings of the American Thoracic Society·Kristen E Belmonte
Nov 4, 2005·Proceedings of the American Thoracic Society·Becky J Proskocil, Allison D Fryer
Dec 3, 2005·American Journal of Respiratory and Critical Care Medicine·Michael E WechslerUNKNOWN National Heart, Lung, and Blood Institute's Asthma Clinical Research Network
Sep 2, 2006·Journal of Human Genetics·Melanie C MathesonMichael J Abramson
Nov 1, 2006·Current Medicinal Chemistry·Fotis SampsonasKostas Spiropoulos

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Citations

Feb 5, 2009·Respirology : Official Journal of the Asian Pacific Society of Respirology·Richard Ruffin, Philip G Bardin
Apr 9, 2009·Respirology : Official Journal of the Asian Pacific Society of Respirology·Martin R J Kolb, Ian Yang
Mar 3, 2012·Chest·Eugene R BleeckerUbaldo J Martin
Dec 14, 2011·International Journal of Chronic Obstructive Pulmonary Disease·L A De BackerW A De Backer
Jul 19, 2013·Pharmacogenomics·Nobuyuki Hizawa
Aug 3, 2011·The Journal of Allergy and Clinical Immunology·Eric D BatemanLeonardo M Fabbri
Jun 29, 2010·Respiratory Medicine·Danilo C BertonJ Alberto Neder
Jun 3, 2016·Current Opinion in Pulmonary Medicine·Justin M OldhamFernando J Martinez
Nov 5, 2016·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Danilo Cortozi BertonPaulo José Zimermann Teixeira
Mar 19, 2009·Therapeutic Advances in Respiratory Disease·Gabriela VaccaAdrian Gillissen
May 23, 2012·Pharmacological Reviews·Mario CazzolaM Gabriella Matera

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